The Five-Choice Continuous Performance Task (5C-CPT): A Cross-Species Relevant Paradigm for Assessment of Vigilance and Response Inhibition in Rodents.
The Five-Choice Continuous Performance Task (5C-CPT): A Cross-Species Relevant Paradigm for Assessment of Vigilance and Response Inhibition in Rodents.
复制标题
五个选择的连续绩效任务（5C-CPT）：用于评估啮齿动物警惕性和反应抑制的跨物种相关范例。
DOI：
10.1002/cpns.20
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发表时间：
2017-01-03
影响因子：
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通讯作者：
Young JW
中科院分区：
文献类型：
--
作者：
Cope ZA;Young JW
注意力和反应抑制领域的缺陷是许多精神疾病的核心。因此，旨在复制这些行为缺陷的疾病动物模型首先需要能够以高保真度准确评估行为的测试。注意力和反应抑制的金标准临床测试是连续操作测试（CPT）。虽然有许多CPT，但都有一个共同的前提，即对目标刺激做出反应，并抑制对非目标刺激的反应。最近开发的啮齿动物五选择CPT（5C-CPT）需要类似的行为反应，使信号检测参数计算。由于啮齿动物试验的可行性，5C-CPT允许/促进：（1）描绘这些行为背后的神经机制;（2）对与精神疾病相关的遗传和环境操纵之间的复杂相互作用进行多因素分析;因此（3）开发新的靶向治疗。迄今为止的所有数据表明，本文所述的啮齿动物5C-CPT可直接转化为临床CPT，在实验动物中产生的行为测量结果与在人类中评估的行为测量结果相当。5C-CPT任务为描述这些机制和开发治疗方法提供了重要工具。然而，它也很复杂，培训时间长，细微差别需要在使用前彻底了解。该单元将使研究人员能够避免潜在的失误，大大增加成功的可能性。
Deficits in the domains of attention and response inhibition are central to many psychiatric disorders. As such, animal models of disorders purporting to replicate these behavioral deficits first require tests that can accurately assess the behaviors with high fidelity. The gold-standard clinical test of attention and response inhibition is the continuous performance test (CPT). Although there are a number of CPTs, all share the premise of responding to target stimuli and inhibiting from responding to non-target stimuli. The recently developed rodent five-choice CPT (5C-CPT) requires similar behavioral responses, enabling signal detection parameter calculations. With demonstrable feasibility for rodent testing, the 5C-CPT permits/facilitates: (1) delineation of neural mechanisms underlying these behaviors; (2) multifactorial analyses of the complex interplay between genetic and environmental manipulations relevant to psychiatric disorders; and hence (3) development of novel targeted treatments. All data to date indicate that the rodent 5C-CPT described here has direct translatability to clinical CPTs, producing equivalent measures of behavior in experimental animals to those assessed in humans. The 5C-CPT task provides an important tool toward delineating these mechanisms and developing treatments. However, it is also complex, with long training times and nuances requiring a thorough understanding before utilization. This unit will enable researchers to avoid potential missteps, greatly increasing the likelihood of success.