Aripiprazole acts as a selective dopamine D2 receptor partial agonist
Aripiprazole acts as a selective dopamine D2 receptor partial agonist
复制标题
阿立哌唑作为选择性多巴胺 D2 受体部分激动剂
DOI：
10.1517/13543784.16.6.771
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发表时间：
2007
影响因子：
6.1
通讯作者：
C. Reavill
中科院分区：
文献类型：
--
作者：
M. Wood;C. Reavill
Aripiprazole has made a significant contribution to the treatment of schizophrenia and related disorders with an improved safety and tolerability profile, which has been attributed to its unique pharmacological profile. It has been claimed that partial agonism of the dopamine D2 and 5-HT1A receptors and antagonism of the 5-HT2 receptor contribute to the clinical profile of aripiprazole, a so-called dopamine- and 5-HT stabiliser. However, recent studies have questioned the role of the 5-HT-mediated systems in the mechanism of action of aripiprazole. This report reviews published and unpublished data that suggest that aripiprazole acts as a selective partial agonist at the dopamine D2 receptor and does not affect 5-HT receptors at therapeutic doses.
