Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology
Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology
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DOI：
10.1111/j.1750-3639.1998.tb00194.x
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发表时间：
1998-10-01
期刊：
影响因子：
6.4
通讯作者：
Lassmann, H
中科院分区：
文献类型：
--
作者：
Storch, MK;Stefferl, A;Lassmann, H
多发性硬化是一种以静脉周围炎症和髓鞘局灶性破坏为特征的慢性炎症性疾病。然而，最近，髓鞘少突胶质细胞糖蛋白（MOG）诱导的自身免疫性脑脊髓炎的新模型变得可用，其以非常标准化和可预测的方式导致慢性脑脊髓炎。在本研究中，我们使用不同的免疫方案在不同的近交系大鼠品系中主动诱导MOG-实验性自身免疫性脑脊髓炎（EAE），在我们的模型中发现的病理学密切反映了多发性硬化（MS）病理学的谱：在用MOG抗原免疫的大鼠中模拟经典MS以及变体如视神经炎、Devic病和马尔堡型急性MS。此外，我们证明，通过使用适当的应变/致敏制度，MS的亚型，例如视神经肌萎缩症，可以重复诱导，我们的研究进一步支持的概念，即发病率和表达的疾病在这个模型中，类似于多发性硬化症的情况，是由遗传和环境因素决定的。
Multiple sclerosis is a chronic inflammatory disease characterized by perivenous inflammation and focal destruction of myelin, Many attempts have been undertaken previously to create animal models of chronic inflammatory demyelinating diseases through autoimmunity or virus infection. Recently, however, a new model of myelin oligodendrocyte glycoprotein (MOG) induced autoimmune encephalomyelitis became available, which, in a very standardized and predictable way, leads to chronic (relapsing or progressive) disease and widespread CNS demyelination.In the present study we actively induced MOG-experimental autoimmune encephalomyelitis (EAE) in different inbred rat strains using different immunization protocols, The pathology found in our models closely reflects the spectrum of multiple sclerosis (MS) pathology: Classical MS as well as variants such as optic neuritis, Devic's disease and Marburg's type of acute MS are mimicked in rats immunized with MOG antigen. Furthermore we demonstrate, that by using the proper strain/sensitization regime, subforms of MS such as for instance neuromyelitis optica can be reproducibly induced, Our study further supports the notion, that incidence and expression of the disease in this model, alike the situation in multiple sclerosis, is determined by genetic and environmental factors.