Standing posture at work and overweight exacerbate varicose veins: Shimane CoHRE Study
Standing posture at work and overweight exacerbate varicose veins: Shimane CoHRE Study
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DOI：
10.1111/1346-8138.12643
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发表时间：
2014-11-01
影响因子：
3.1
通讯作者：
Shiwaku, Kuninori
中科院分区：
文献类型：
--
作者：
Kohno, Kunie;Niihara, Hiroyuki;Shiwaku, Kuninori
下肢静脉曲张（VV）在全球人群中普遍存在。然而，VV在日本的流行程度和危险因素尚不清楚。本研究旨在了解岛根县传统农村地区流行性腮腺炎的危险因素。研究对象（45岁的113名男性和205名女性）于2012年从这些地区的健康检查中招募。VV被定义为超声检查发现的大隐静脉和/或小隐静脉及不功能穿静脉的血液回流。使用包含各种参数的逻辑回归模型分析VV的危险因素。我们还调查了站立工作与超重之间可能的相互作用，并计算了协同指数。20.1%的受试者（男性12.4%，女性24.4%）存在VV。先前已知的工作时长时间直立站立姿势、较高的身体质量指数（BMI）、女性性别和年龄也是VV的重要因素。体重超重（BMI 25）和长时间直立站立对工作有显著的综合影响[校正优势比=3.42；95%可信区间（CI）， 1.07-10.89]，尽管协同效应不显著[协同指数=1.3；95% ci, 0.2-8.7]。岛根县传统农村地区流行性腮腺炎的流行情况与以前在欧洲国家报告的情况相当。我们的研究结果证实，长时间站立和超重都会加剧VV的发展。这一发现有助于制定VV预防策略。
Varicose veins (VV) in legs are commonly observed in the general global population. However, the prevalence of and risk factors for VV in Japan are not clear. This study aimed at clarifying the risk factors for VV in traditional rural areas of Shimane prefecture. Subjects (113 men and 205 women aged 45years) were recruited from health examinations in those areas in 2012. VV were defined as a reflux of blood in the great and/or small saphenous vein and incompetent perforating veins detected by ultrasonography. Risk factors for VV were analyzed using logistic regression models that included various parameters. We also investigated the possible interaction between standing at work and overweight and calculated the synergistic index. VV were found in 20.1% of the subjects (12.4% of men and 24.4% of women). The previously known risk factors of prolonged upright standing posture during work, higher body mass index (BMI), female sex, and age were also significant factors for VV. There was a significant combined effect of overweight (BMI 25) and prolonged upright standing posture at work [adjusted odds ratio=3.42; 95% confidence interval (CI), 1.07-10.89], although the synergistic effect was not significant [synergistic index=1.3; 95% CI, 0.2-8.7]. The prevalence of VV in the traditional rural area of Shimane prefecture was comparable to that reported previously in European countries. Our results confirm that exposure to both prolonged standing at work and overweight exacerbate VV development. This finding is useful to develop strategies for VV prevention.