Desmosomal component expression in normal, dysplastic, and oral squamous cell carcinoma.
Desmosomal component expression in normal, dysplastic, and oral squamous cell carcinoma.
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DOI：
10.1155/2010/649731
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发表时间：
2010
影响因子：
1.5
通讯作者：
Wahl JK
中科院分区：
文献类型：
--
作者：
Narayana N;Gist J;Smith T;Tylka D;Trogdon G;Wahl JK
鳞状细胞癌（口腔SCC）是美国最常见的口腔癌，每年影响近3万美国人尽管最近在检测和治疗方面取得了进展，但这种毁灭性疾病的五年生存率几乎没有改善。口腔癌之前可能有组织学上表现为发育异常的癌前病变。识别细胞变化的分子标志物将有助于确定口腔鳞状细胞癌进展为异型增生的风险。本研究的目的是确定组织学诊断的不典型增生和口腔鳞状细胞癌病变之间是否存在任何相关性，以及口腔上皮中桥粒细胞-细胞粘附分子表达的改变。我们的数据显示，口腔鳞状细胞癌组织样本显示，与正常口腔上皮相比，桥粒斑蛋白和斑嗜蛋白-1的免疫反应性降低。此外，与正常口腔上皮相比，在异型增生组织中观察到桥粒斑蛋白免疫反应性显著降低。相比之下，桥粒芯糖蛋白-1染色的水平在样品之间是不变的，然而在口腔SCC样品中发现桥粒芯糖蛋白-1定位于细胞边界。这些数据表明，桥粒斑蛋白和斑嗜蛋白-1的表达的变化可能被证明是一个有用的标志物的组织形态学的变化，并提供了一个工具，用于识别口腔癌前病变。
Squamous cell carcinoma (oral SCC) is the most common oral cancer in the U.S., affecting nearly 30,000 Americans each year. Despite recent advances in detection and treatment, there has been little improvement in the five-year survival rate for this devastating disease. Oral cancer may be preceded by premalignant disease that appears histologically as dysplasia. Identification of molecular markers for cellular change would assist in determining the risk of dysplasia progressing to oral squamous cell carcinoma. The goal of this study was to determine if any correlation exists between histological diagnosed dysplasia and OSCC lesions and altered expression of desmosomal cell-cell adhesion molecules in the oral epithelium. Our data showed that oral SCC tissue samples showed decreased immunoreactivity of both desmoplakin and plakophilin-1 proteins compared to normal oral epithelium. Furthermore, significant decrease in desmoplakin immunoreactivity was observed in dysplastic tissue compared to normal oral epithelium. In contrast, the level of desmoglein-1 staining was unchanged between samples however desmoglein-1 was found localized to cell borders in oral SCC samples. These data suggest that changes in expression of desmoplakin and plakophilin-1 may prove to be a useful marker for changes in tissue morphology and provide a tool for identifying pre-neoplastic lesions of the oral cavity.