Antidotal Effects of the Phenothiazine Chromophore Methylene Blue Following Cyanide Intoxication
Antidotal Effects of the Phenothiazine Chromophore Methylene Blue Following Cyanide Intoxication
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DOI：
10.1093/toxsci/kfz081
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发表时间：
2019-07-01
影响因子：
3.8
通讯作者：
Bouillaud, Frederic
中科院分区：
文献类型：
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作者：
Haouzi, Philippe;McCann, Marissa;Bouillaud, Frederic
我们的研究旨在（1）确定染料亚甲蓝（MB）在未镇静大鼠中快速致死的氰化物（CN）中毒后的效力;（2）阐明这种有效的环状氧化还原染料产生解毒特性的一些机制。69只清醒的CN（IP，KCN 7 mg/kg）急性中毒大鼠，在深度昏迷状态下分别给予生理盐水、MB（20 mg/kg）或羟钴胺（HyCo，150 mg/kg）。在该模型中的存活率非常低，在没有任何处理的情况下在60分钟时达到9%。亚甲蓝显著提高了存活率（59%，p
Our study was aimed at (1) determining the efficacy of the dye methylene blue (MB), following a rapidly lethal cyanide (CN) intoxication in un-sedated rats; (2) clarifying some of the mechanisms responsible for the antidotal properties produced by this potent cyclic redox dye. Sixty-nine awake rats acutely intoxicated by CN (IP, KCN 7mg/kg) received saline, MB (20mg/kg) or hydroxocobalamin (HyCo, 150mg/kg) when in deep coma. Survival in this model was very low, reaching 9% at 60min without any treatment. Methylene blue significantly increased survival (59%, p