The effect of folic acid fortification on plasma folate and total homocysteine concentrations
The effect of folic acid fortification on plasma folate and total homocysteine concentrations
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DOI：
10.1056/nejm199905133401901
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发表时间：
1999-05-13
影响因子：
158.5
通讯作者：
Rosenberg, IH
中科院分区：
文献类型：
--
作者：
Jacques, PF;Selhub, J;Rosenberg, IH
背景1996年，美国食品和药物管理局(Food And Drug Administration)发布了一项规定，要求所有强化谷物产品都要添加叶酸，以降低新生儿神经管缺陷的风险。强化(140微克/100克)始于1996年，到1997年年中基本完成。方法为了评估强化叶酸对叶酸状态的影响，我们用第五次检查(1991年1月至1994年12月)和第六次检查(1995年1月至1998年8月)的血样测定血浆叶酸和总同型半胱氨酸浓度(叶酸状态的敏感标志物)，作为基线和第六次检查(1995年1月至1998年8月)。结果未服用维生素补充剂的研究组中，叶酸平均浓度由4.6 ng/毫升上升至10.0 ng/L(11~23 nmol/L)(P<0.05)；
Background In 1996, the Food and Drug Administration issued a regulation requiring all enriched grain products to be fortified with folic acid to reduce the risk of neural-tube defects in newborns. Fortification (140 mu g per 100 g) began in 1996, and the process was essentially complete by mid-1997.Methods To assess the effect of folic acid fortification on folate status, we measured plasma folate and total homocysteine concentrations (a sensitive marker of folate status) using blood samples from the fifth examination (January 1991 to December 1994) of the Framingham Offspring Study cohort for baseline values and the sixth examination (January 1995 to August 1998) for follow-up values. We divided the cohort into two groups on the basis of the date of their follow-up examination: the study group consisted of 350 subjects who were seen after fortification (September 1997 to March 1998), and the control group consisted of 756 subjects who were seen before fortification (January 1995 to September 1996).Results Among the subjects in the study group who did not use vitamin supplements, the mean folate concentrations increased from 4.6 to 10.0 ng per milliliter (11 to 23 nmol per liter) (P