Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.
Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.
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过氧化还原蛋白参与多发性硬化症和视神经脊髓炎谱系疾病的发病机制。
DOI：
10.1111/cei.13487
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Kuwabara S.
中科院分区：
文献类型：
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作者：
Uzawa A;Mori M;Masuda H;Ohtani R;Uchida T;Aoki R;Kuwabara S.
过氧化还蛋白(Prooxiredoxins，PRX)是细胞内的抗氧化酶，但在细胞外的条件下起到炎症放大的作用。到目前为止，PRX在多发性硬化症(MS)和视神经脊髓炎谱系障碍(NMOSD)发病机制中的作用还不完全清楚。本研究的目的是探讨PRX是否在MS和NMOSD的发病机制中起作用。我们分析了16例MS患者、16例NMOSD患者和15例其他神经系统疾病(ODS)患者脑脊液(CSF)和血清中PRXs(PRX1、PRX5和PRX6)的水平。我们确定了MS和NMOSD患者显著升高的PRXs水平与临床变量之间的潜在相关性。此外，采用MS的实验性自身免疫性脑脊髓炎(EAE)动物模型对中枢神经系统(CNS)中PRXs(PRX1-6)进行了病理分析。结果发现，MS和NMOSD患者的血清PRX5和PRX6水平均高于ONS患者(P<；P<0.05)。此外，在NMOSD患者中，高水平的PRX5和PRX6部分与血脑屏障功能障碍和病程有关。脑脊液中MS和NMOSD的PRXs水平未见明显升高。EAE小鼠脊髓内有明显的PRX5染色，尤其是CD45+细胞。结论：PRX5和PRX6可能在MS和NMOSD的发病机制中起一定作用。
Peroxiredoxins (PRXs) are intracellular anti-oxidative enzymes but work as inflammatory amplifiers under the extracellular condition. To date, the function of PRXs in the pathogenesis of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) is not fully understood. The aim of this study was to investigate whether PRXs play a role in the pathogenesis of MS and NMOSD. We analyzed levels of PRXs (PRX1, PRX5 and PRX6) in the cerebrospinal fluid (CSF) and serum of 16 patients with MS, 16 patients with NMOSD and 15 patients with other neurological disorders (ONDs). We identified potential correlations between significantly elevated PRXs levels and the clinical variables in patients with MS and NMOSD. Additionally, pathological analyses of PRXs (PRX1-6) in the central nervous system (CNS) were performed using the experimental autoimmune encephalomyelitis (EAE), animal model of MS. We found that serum levels of PRX5 and PRX6 in patients with MS and NMOSD were higher compared with those in patients with ONDs (P< 0·05). Furthermore, high levels of PRX5 and PRX6 were partly associated with blood–brain barrier dysfunction and disease duration in NMOSD patients. No significant elevation was found in CSF PRXs levels of MS and NMOSD. Spinal cords from EAE mice showed remarkable PRX5 staining, especially in CD45+infiltrating cells. In conclusion, PRX5 and PRX6 may play a role in the pathogeneses of MS and NMOSD.