Noninvasive quantification of jeopardized myocardial mass in dogs using 2-dimensional echocardiography and thallium-201 tomography.
Noninvasive quantification of jeopardized myocardial mass in dogs using 2-dimensional echocardiography and thallium-201 tomography.
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使用二维超声心动图和铊 201 断层扫描对狗的受损心肌质量进行无创定量。
DOI：
10.1016/0002-9149(83)90598-2
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
B. Pitt
中科院分区：
文献类型：
--
作者：
R. Weiss;A. Buda;S. Pasyk;W. O’Neill;J. Keyes;B. Pitt
评价受损心肌质量对于确定心肌梗死期间干预措施的效果非常重要。为了定量在体内质量的风险，二维超声心动图（2-D回声）和铊-201单光子发射计算机断层扫描（SPECT）进行了10个闭胸犬后回旋冠状动脉闭塞。手动数字化的2-D图像计算左心室（LV）的质量使用修改后的辛普森规则算法。LV质量的测量与实际LV质量相关良好（r = 0.97）。灌注心肌质量估计从铊SPECT图像闭塞后4小时，使用区域生长算法。在犬被杀死后，使用氯化三苯基四唑和伊文思蓝染料的双重灌注染色技术勾勒出危害质量。通过铊图像很好地估计了实际灌注质量（r = 0.96）。非侵入性确定的风险质量计算为：2-D质量-铊SPECT质量，并与病理确定的风险质量相关（r = 0.91）。因此，可以通过使用2-D回波和铊-201断层扫描非侵入性地确定危害质量。这种方法可以提供关于介入治疗对受损心肌的影响的进一步信息。
The evaluation of jeopardized myocardial mass is important in defining the effect of interventions during myocardial infarction. To quantitate the in vivo mass at risk, 2-dimensional echocardiography (2-D echo) and thallium-201 single-photon emission computed tomography (SPECT) was performed in 10 closed-chest dogs after circumflex coronary artery occlusion. The 2-D images were manually digitized to compute left ventricular (LV) mass using a modified Simpson's rule algorithm. This measure of LV mass correlated well with the actual LV mass (r = 0.97). Perfused myocardial mass was estimated from thallium SPECT images 4 hours after occlusion using a region-growing algorithm. After the dogs were killed, the jeopardized mass was outlined using a dual perfusion staining technique using triphenyltetrazolium chloride and Evans blue dye. The actual perfused mass was well estimated by the thallium images (r = 0.96). The noninvasively determined mass at risk was calculated as: 2-D mass — thallium SPECT mass, and correlated well with the pathologically determined mass at risk (r = 0.91). Thus, the jeopardized mass may be determined noninvasively by using 2-D echo and thallium-201 tomography. This approach may provide further information regarding the effect of intervention therapy on jeopardized myocardium.
根据铊 201 断层扫描计算活心肌和梗塞心肌质量。
DOI：
--
发表时间：
1981
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
KeyesJr,JW;Brady,TJ;Leonard,PF;Svetkoff,DB;Winter,SM;Rogers,WL;Rose,EA
通讯作者：
Rose,EA