Not everything, not everywhere, not all at once: a study of brain-wide encoding of movement.
Not everything, not everywhere, not all at once: a study of brain-wide encoding of movement.
复制标题
不是一切，不是到处，也不是同时：对全脑运动编码的研究。
DOI：
10.1101/2023.06.08.544257
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Druckmann,Shaul
中科院分区：
文献类型：
--
作者：
Wang,ZiyueAiden;Chen,Susu;Liu,Yi;Liu,Dave;Svoboda,Karel;Li,Nuo;Druckmann,Shaul
与运动相关的活动遍布大脑的感觉和运动区域。然而，目前还不清楚运动相关的活动如何分布在大脑中，以及大脑区域之间是否存在系统性差异。在这里，我们分析了在执行决策任务的小鼠中包含超过50，000个神经元的全脑记录中的运动相关活动。使用从标记到深度神经网络的多种技术，我们发现与运动相关的信号在大脑中无处不在，但在不同区域之间存在系统性差异。运动相关活动在靠近运动或感觉周边的区域更强。根据感觉和运动相关的成分描述活动，揭示了大脑区域内编码的更精细尺度结构。我们进一步确定了与决策和未经指导的运动相关的活动调制。我们的工作绘制了一个大规模的运动编码地图，并提供了一个路线图，用于解剖不同形式的运动和跨多区域神经回路的决策相关编码。
Activity related to movement is found throughout sensory and motor regions of the brain. However, it remains unclear how movement-related activity is distributed across the brain and whether systematic differences exist between brain areas. Here, we analyzed movement related activity in brain-wide recordings containing more than 50,000 neurons in mice performing a decision-making task. Using multiple techniques, from markers to deep neural networks, we find that movement-related signals were pervasive across the brain, but systematically differed across areas. Movement-related activity was stronger in areas closer to the motor or sensory periphery. Delineating activity in terms of sensory- and motor-related components revealed finer scale structures of their encodings within brain areas. We further identified activity modulation that correlates with decision-making and uninstructed movement. Our work charts out a largescale map of movement encoding and provides a roadmap for dissecting different forms of movement and decision-making related encoding across multi-regional neural circuits.