The endocrinology of pre‐eclampsia
The endocrinology of pre‐eclampsia
复制标题
先兆子痫的内分泌学
作者：
N. Page
子痫前期是一种妊娠特有的综合征，是孕产妇发病率和死亡率的主要原因，占妊娠相关死亡的近15%，也是新生儿医源性早产的主要原因之一。轻度先兆子痫最常见的特征是母体高血压和蛋白尿，但可能会迅速和不可预测地变得严重，出现许多涉及母体肝、肾、肺、血液和血小板凝固以及神经系统的多系统并发症。先兆子痫的各种症状使其不仅难以定义，而且难以确定这些症状的病原体。该综述探讨了导致子痫前期广泛并发症的复杂内分泌机制，从胎盘和内皮功能障碍的作用，到氧化应激和随之而来的全身炎症的原因。它还强调了目前内分泌的发现，这些发现显示了作为潜在标记物或新的治疗靶点的临床应用的潜力，目的是预防或改变这种危及生命的妊娠疾病的进程。
Pre‐eclampsia is a pregnancy specific syndrome that is a principal cause of maternal morbidity and mortality, accounting for almost 15% of pregnancy associated deaths, and is one of the major causes of iatrogenic prematurity among new born babies. The mild form of pre‐eclampsia most commonly presents with the features of maternal hypertension and proteinuria, but can swiftly and unpredictably become severe with numerous multisystem complications involving the maternal liver, kidneys, lungs, blood and platelet coagulation and nervous systems. The diverse symptoms of pre‐eclampsia have made it a difficult disease not only to define, but also to identify a causative agent for the symptoms. This review examines the complex endocrinological mechanisms believed to be responsible for the extensive complications of pre‐eclampsia from the role of placental and endothelial dysfunction, to the causes of the oxidative stress and the ensuing general inflammation. It also highlights current endocrine findings that exhibit the potential for clinical application, as either potential markers or novel therapeutic targets, with the aim of either preventing or altering the course of this life‐threatening disease of pregnancy.
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影响因子：
3.1
作者：
Weiguo Wang;Scott L. Diamond
通讯作者：
Weiguo Wang;Scott L. Diamond
DOI：
10.1016/0002-9378(89)90665-0
发表时间：
1989-11-01
影响因子：
9.8
作者：
ROBERTS, JM;TAYLOR, RN;MCLAUGHLIN, MK
通讯作者：
MCLAUGHLIN, MK
先兆子痫与脂蛋白脂肪酶基因中常见编码序列变异的关联。
影响因子：
3.5
作者：
Hubel,CA;Roberts,JM;Ferrell,RE
通讯作者：
Ferrell,RE
促肾上腺皮质激素释放激素结合蛋白（CRH-BP）：正常人类妊娠晚期的血浆水平降低。
DOI：
10.1210/jcem.76.1.8421097
发表时间：
1993
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Linton,EA;Perkins,AV;Woods,RJ;Eben,F;Wolfe,CD;Behan,DP;Potter,E;Vale,WW;Lowry,PJ
通讯作者：
Lowry,PJ
影响因子：
9.8
作者：
Yuping Wang;S. Walsh;H. Kay
通讯作者：
Yuping Wang;S. Walsh;H. Kay