Plasma insulin-like growth factor I is inversely associated with colorectal adenoma recurrence:: A novel hypothesis
Plasma insulin-like growth factor I is inversely associated with colorectal adenoma recurrence:: A novel hypothesis
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DOI：
10.1158/1055-9965.epi-07-0764
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发表时间：
2008-02-01
影响因子：
3.8
通讯作者：
Thompson, Patricia A.
中科院分区：
文献类型：
--
作者：
Jacobs, Elizabeth T.;Martinez, Maria Elena;Thompson, Patricia A.
胰岛素样生长因子I（IGF-I）轴已被认为是某些癌症（包括结直肠癌）发生的重要因素。然而，流行病学研究结果表明，对结直肠癌风险的影响不大。采用横断面和前瞻性研究设计，在基线时至少有一个腺瘤的同一队列男性中，我们研究了血浆IGF-I、IGF-I结合蛋白1和IGF-I结合蛋白3是否与基线时结直肠腺瘤特征相关，以及它们的水平是否与腺瘤复发的几率相关。测量了299名参与麦麸纤维试验的男性参与者的基线血浆中每种标记物的水平，并对他们的腺瘤性病变复发进行了前瞻性随访。在横断面分析中，血浆IGF-I与任何绒毛状特征的腺瘤的存在显著正相关（P = 0.04）。相反，IGF-I水平与结直肠腺瘤复发的几率呈负相关，与第一个三分位数相比，IGF-I第二个和第三个三分位数的调整后的比值比（95%置信区间）分别为0.55（0.29-1.01）和0.49（0.26-0.91）（P趋势= 0.02）。与非晚期复发（P趋势0.10）相比，晚期腺瘤复发（P趋势0.02）的负相关性更强。这些结果表明，一旦腺瘤被切除，较高的IGF-I水平降低了结直肠新病变形成的几率。
The insulin-like growth factor I (IGF-I) axis has been proposed to be a significant factor in the development of certain cancers, including colorectal. However, results from epidemiologic studies suggest modest effects on colorectal cancer risk. Using cross-sectional and prospective study designs within the same cohort of men who had at least one adenoma at baseline, we investigated whether plasma IGF-I, IGF-I binding protein 1, and IGF-I binding protein 3 were associated with colorectal adenoma characteristics at baseline and whether their levels were related to odds for adenoma recurrence. Plasma levels of each marker were measured at baseline in 299 male participants in the Wheat Bran Fiber Trial, who were followed prospectively for recurrence of their adenomatous lesions. In cross-sectional analyses, plasma IGF-I was significantly positively associated with the presence of adenomas with any villous features (P = 0.04). In contrast, IGF-I levels were inversely associated with odds of colorectal adenoma recurrence, with adjusted odds ratios (95% confidence interval) of 0.55 (0.29-1.01) and 0.49 (0.26-0.91) for the second and third tertiles of IGF-I, respectively, compared with the first tertile (P-trend = 0.02). The inverse association was stronger for advanced adenoma recurrence (P-trend 0.02) than for non-advanced recurrence (P-trend 0.10). These results suggest that, once an adenoma is removed, higher IGF-I levels reduce the odds of the formation of new lesions in the colorectum.