Neuroimaging evidence for dissociable forms of repetition priming
Neuroimaging evidence for dissociable forms of repetition priming
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DOI：
10.1126/science.287.5456.1269
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发表时间：
2000-02-18
期刊：
影响因子：
56.9
通讯作者：
Dolan, R
中科院分区：
文献类型：
--
作者：
Henson, R;Shallice, T;Dolan, R
重复启动的神经生理学特征是刺激重复后反应减弱。本研究使用事件相关功能磁共振成像来研究这种重复相关的反应是否对刺激熟悉度敏感。右侧梭形区域对熟悉刺激的重复反应减弱，但对陌生刺激的重复反应增强。此外，两种重复效应都被连续呈现之间的滞后所调节。进一步的实验复制了重复、熟悉和滞后之间的交互作用，并证明了这些效应在多次重复时的持久性。因此，与启动相关的反应并不是一元性的，而是取决于是否存在预先存在的刺激表征。
Repetition priming has been characterized neurophysiologically as a decreased response following stimulus repetition. The present study used event-related functional magnetic resonance imaging to investigate whether this repetition-related response is sensitive to stimulus familiarity. A right fusiform region exhibited an attenuated response to the repetition of familiar stimuli, both faces and symbols, but exhibited an enhanced response to the repetition of unfamiliar stimuli. Moreover, both repetition effects were modulated by lag between successive presentations. Further experiments replicated the interactions between repetition, familiarity, and lag and demonstrated the persistence of these effects over multiple repetitions. Priming-related responses are therefore not unitary but depend on the presence or absence of preexisting stimulus representations.