Plasma hydrogen peroxide production in human essential hypertension -: Role of heredity, gender, and ethnicity
Plasma hydrogen peroxide production in human essential hypertension -: Role of heredity, gender, and ethnicity
复制标题
DOI：
10.1161/01.hyp.36.5.878
复制
发表时间：
2000-11-01
期刊：
影响因子：
8.3
通讯作者：
Parmer, RJ
中科院分区：
文献类型：
--
作者：
Lacy, F;Kailasam, MT;Parmer, RJ
氧自由基，包括过氧化氢，可能介导靶器官组织的氧化应激，并导致高血压的心血管并发症。为了检验过氧化氢产生的遗传性，我们调查了通过高血压先证者(n=57)确定的由家庭成员(n=236)组成的基于家庭的队列中的这一特征。性别和种族对过氧化氢的产生有显著影响，男性的价值观高于女性(P
Oxygen free radicals, including hydrogen peroxide, may mediate oxidative stress in target organ tissues and contribute to cardiovascular complications in hypertension. To examine heritability of hydrogen peroxide production, we investigated this trait in a family-based cohort consisting of family members (n=236) ascertained through probands (n=57) with essential hypertension. Significant effects on hydrogen peroxide production were found for gender and ethnicity, with men having greater values than women (P