Response inhibition impairment in high functioning autism and attention deficit hyperactivity disorder: evidence from near-infrared spectroscopy data.
Response inhibition impairment in high functioning autism and attention deficit hyperactivity disorder: evidence from near-infrared spectroscopy data.
复制标题
高功能自闭症和注意力缺陷多动障碍的反应抑制损伤：近红外光谱数据的证据
DOI：
10.1371/journal.pone.0046569
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Xiao T;Xiao Z;Ke X;Hong S;Yang H;Su Y;Chu K;Xiao X;Shen J;Liu Y
背景反应抑制是执行功能的一个重要领域，涉及对无关或干扰信息和冲动的抑制能力。以前的研究表明，高功能自闭症（HFA）和注意缺陷多动障碍（ADHD）的反应抑制受损，但最近的研究结果不一致。迄今为止，几乎没有研究已经进行了使用功能成像技术直接比较HFA和ADHD儿童之间的抑制控制。方法对19例HFA儿童、16例年龄和智商（IQ）匹配的ADHD儿童和16例正常发育（TD）儿童进行Go/No-go和Stroop任务时的功能近红外光谱（NIRS）成像。结果与TD组相比，HFA组和ADHD组儿童在No-go阻滞中的反应时间更长，HFA组反应时间最长，TD组反应时间最短。HFA和ADHD组的儿童在No-go块中的反应错误数量也比TD组的儿童多。在Stroop任务中，三组被试在反应时和遗漏错误方面没有显著差异。与TD组相比，HFA组和ADHD组在No-go阻滞期间右前额叶皮层（PFC）的失活水平更高。然而，在Stroop任务中，两组PFC中的氧合血红蛋白浓度水平无显著差异。结论近红外脑功能成像显示HFA和ADHD儿童在抑制任务中右侧PFC的激活减少，表明抑制功能障碍是HFA和ADHD的共同特征。
Background Response inhibition, an important domain of executive function (EF), involves the ability to suppress irrelevant or interfering information and impulses. Previous studies have shown impairment of response inhibition in high functioning autism (HFA) and attention deficit hyperactivity disorder (ADHD), but more recent findings have been inconsistent. To date, almost no studies have been conducted using functional imaging techniques to directly compare inhibitory control between children with HFA and those with ADHD. Method Nineteen children with HFA, 16 age- and intelligence quotient (IQ)-matched children with ADHD, and 16 typically developing (TD) children were imaged using functional near-infrared spectroscopy (NIRS) while performing Go/No-go and Stroop tasks. Results Compared with the TD group, children in both the HFA and ADHD groups took more time to respond during the No-go blocks, with reaction time longest for HFA and shortest for TD. Children in the HFA and ADHD groups also made a greater number of reaction errors in the No-go blocks than those in the TD group. During the Stroop task, there were no significant differences between these three groups in reaction time and omission errors. Both the HFA and ADHD groups showed a higher level of inactivation in the right prefrontal cortex (PFC) during the No-go blocks, relative to the TD group. However, no significant differences were found between groups in the levels of oxyhemoglobin concentration in the PFC during the Stroop task. Conclusion Functional brain imaging using NIRS showed reduced activation in the right PFC in children with HFA or ADHD during an inhibition task, indicating that inhibitory dysfunction is a shared feature of both HFA and ADHD.