Characteristics and outcomes of acute-on-chronic liver failure patients with or without cirrhosis using two criteria
Characteristics and outcomes of acute-on-chronic liver failure patients with or without cirrhosis using two criteria
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DOI：
10.1038/s41598-020-65529-5
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发表时间：
2020-05-22
影响因子：
4.6
通讯作者：
Cao, Hongcui
中科院分区：
文献类型：
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作者：
Dong, Xiaotian;He, Jianqin;Cao, Hongcui
本研究的目的是使用两种标准确定慢性加急性肝衰竭（ACLF）患者伴或不伴肝硬化的特征和结局。回顾性纳入2016年4月10日至2019年4月10日期间慢性肝病急性恶化或肝硬化急性失代偿患者。除考虑肝硬化外，采用欧洲肝脏慢性肝衰竭研究协会（EASL-CLIF）标准和中国重型B型肝炎研究组（COSSH）标准。比较ACLF合并肝硬化与不合并肝硬化患者的临床特征、实验室检查资料及生存曲线。共纳入799例患者。其中COSSH合并EASL ACLF 328例，单纯COSSH 197例，单纯EASL 104例。COSSH标准ACLF多11.6%。此外，非肝硬化与肝硬化的EASL ACLF患者具有不同的实验室特征：ALT（423 vs. 154，p
The aim of the study was to identify the characteristics and outcomes in acute-on-chronic liver failure (ACLF) patients with or without cirrhosis using two criteria. Patients with acute deterioration of chronic hepatic disease or acute decompensation of cirrhosis were included retrospectively from April 10, 2016 to April 10, 2019. European Association for the Study of the Liver-chronic liver failure (EASL-CLIF) criterion except for consideration of cirrhosis and Chinese Group on the Study of Severe Hepatitis B (COSSH) criterion were used. Clinical features, laboratory data and survival curves were compared between the ACLF patients with and without cirrhosis. A total of 799 patients were included. Among them, 328 had COSSH and EASL ACLF, 197 had COSSH alone, and 104 had EASL alone. There were 11.6% more ACLF with COSSH criterion. Furthermore, EASL ACLF patients with non-cirrhosis vs. cirrhosis had different laboratory characteristics: ALT (423 vs. 154, p