How to Define the Latent Reservoir: Tools of the Trade.
How to Define the Latent Reservoir: Tools of the Trade.
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DOI：
10.1007/s11904-016-0304-1
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发表时间：
2016-04
影响因子：
4.6
通讯作者：
Palmer SE
中科院分区：
文献类型：
--
作者：
Barton KM;Palmer SE
艾滋病毒是一种毁灭性的世界性流行病，在全球范围内产生了重大的社会和经济影响。由于在抗逆转录病毒治疗(ART)期间存在少量潜伏感染的细胞池，艾滋病毒是不可治愈的。由于艺术品的高成本和在全球范围内缺乏可靠的可及性，终身艺术品不幸地不是应对这一流行病的可行方案。因此，需要制定和实施新的战略来解决艾滋病毒-1感染问题。目前正在调查几种实现这一目标的方法(Ebina等人。收录于《科学报告》3：2510；Archin等人。《自然》487：482-5；Elliott等人。在PLoS pathog 10中：e1004473，；Rasmussen等人。在《柳叶刀》艾滋病毒1：e13-e21中；Tebas等人。在N Engl J Med 370：901-10，；Archin等人。收录于NAT Rev Microbiol 12：750--；巴顿等人。在PLoS one 9：e102684中；Sogaard等人。在PLoS parog 11中：e1005142，)。初步研究被证明是有希望的，但强调了需要灵敏和准确的分析来检测极低浓度病毒的变化，以便对治疗方法的成功进行有信心的解释。本综述将重点介绍目前可用的分析方法以及每种方法的优点和局限性。
HIV is a devastating worldwide epidemic that has had substantial social and economic impacts throughout the globe. Due to the presence of a small pool of latently infected cells that persists during antiretroviral therapy (ART), HIV is not curable. Because of the high cost of ART and the lack of reliable accessibility across the globe, life-long ART is unfortunately not a feasible solution for the epidemic. Therefore, new strategies need to be developed and implemented to address HIV-1 infection. Several approaches toward this end are currently under investigation (Ebina et al. in Sci Rep 3:2510,; Archin et al. in Nature 487:482–5,; Elliott et al. in PLoS Pathog 10:e1004473,; Rasmussen et al. in Lancet HIV 1:e13–e21,; Tebas et al. in N Engl J Med 370:901–10,; Archin et al. in Nat Rev Microbiol 12:750–64,; Barton et al. in PLoS One 9:e102684,; Sogaard et al. in PLoS Pathog 11:e1005142,). Initial studies have proven promising, but have highlighted the need for sensitive and accurate assays to detect changes in very low concentrations of virus to allow confident interpretation of the success of curative approaches. This review will focus on assays that are currently available and the advantages and limitations of each.