Targeting lysosomal Ca2+ to reduce reperfusion injury.
Targeting lysosomal Ca2+ to reduce reperfusion injury.
复制标题
靶向溶酶体 Ca2 以减少再灌注损伤。
DOI：
10.1093/cvr/cvv242
复制
发表时间：
2015
期刊：
影响因子：
10.8
通讯作者：
Kitakaze M.
中科院分区：
文献类型：
--
作者：
Tsukamoto O;Asanuma H;Kitakaze M.
经皮冠状动脉介入治疗（PCI）在急性心肌梗死（AMI）患者中的应用已成功降低了相关死亡率和/或发病率。然而，尽管PCI广泛使用，但缺血性心力衰竭的患病率有所增加，这主要归因于这种治疗在限制梗死面积方面不如预期成功。由于减少梗死面积对于减少心力衰竭的发生至关重要，单独PCI不足以降低AMI后缺血性心力衰竭的发生率。为了克服这一挑战，许多研究人员已经研究了缺血和再灌注损伤的主要原因以及减轻由它们引起的损伤的方法。1
The use of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has successfully reduced the incidence of associated mortality and/or morbidity. However, despite widespread use of PCI, there has been an increase in the prevalence of ischaemic heart failure, which is mainly attributable to the fact that this treatment has not been as successful as expected in limiting the size of infarcts. Because reducing the infarct size is essential to decrease the development of heart failure, PCI alone is not sufficient to reduce the incidence of ischaemic heart failure following AMI. To overcome this challenge, many researchers have investigated the major causes of ischaemia and reperfusion injury and methods to attenuate the damage caused by them. 1