Expression of Galectin-3 in Pancreatic Ductal Adenocarcinoma
Expression of Galectin-3 in Pancreatic Ductal Adenocarcinoma
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DOI：
10.1007/s12253-011-9444-1
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发表时间：
2012-04-01
影响因子：
2.8
通讯作者：
Wente, Moritz N.
中科院分区：
文献类型：
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作者：
Gaida, Matthias M.;Bach, Sylvia T.;Wente, Moritz N.
Galectin-3影响新血管生成、肿瘤细胞黏附和肿瘤免疫逃逸机制。因此，我们研究Galectin-3在胰腺导管腺癌(PDAC)中的表达。半乳糖凝集素-3在PDAC细胞系中的表达通过细胞内蛋白的存在和释放到上清液中得到证实。此外，在大多数人体组织样本中都发现了Galectin-3。PDAC患者的血清Galectin-3浓度与健康献血者没有显著差异，也与已建立的肿瘤标志物无关。总之，Galectin-3在PDAC组织中表达，提示在肿瘤的发展中起作用；然而，表达与临床结果之间的关系尚不能确定。
Galectin-3 influences neoangiogenesis, tumor cell adhesion, and tumor-immune-escape mechanisms. Hence, the expression of galectin-3 in pancreatic ductal adenocarcinoma (PDAC) was evaluated. Galectin-3 expression in PDAC cell lines was proven by the presence of intracellular protein and by release into the supernatant. Furthermore, galectin-3 was found in the majority of human tissue samples. Serum concentrations of galectin-3 in PDAC patients did not differ significantly from healthy donors and did not correlate with established tumor markers. In conclusion, galectin-3 is expressed in PDAC tissues suggesting a role in tumor development; however, no relationship between expression and clinical findings could be established.