Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references
Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references
复制标题
DOI：
10.1016/j.ejrad.2008.04.013
复制
发表时间：
2009-08-01
影响因子：
3.3
通讯作者：
Akeson, Per
中科院分区：
文献类型：
--
作者：
Diaz, Sandra;Casselbrant, Ingrid;Akeson, Per
目的：将超极化 (HP) 氦气 (He-3) 磁共振成像 (MRI) 的表观扩散系数 (ADC) 测量值与全肺多层计算机断层扫描 (CT) (MSCT) 和肺功能测试 (PFT) 的定量数据进行比较。材料和方法：对 27 名受试者进行 Hp 检查，其中 22 名患有已确定的肺气肿，5 名患有根据 PFT 标准定义的临床前肺气肿He-3-MRI 和 MSCT。平均年龄为 55 (+/- 12) 岁，其中 18 名女性和 9 名男性。将 He-3-MRI 的平均 ADC 与 MSCT 的肺气肿指数 (EI)、第 15 个百分位数和平均肺密度 (MLD) 值进行比较。使用 Pearson 相关性检验将平均 ADC 和 MSCT 数据与 PFT 进行比较，尤其是预测一氧化碳扩散能力的百分比 (%预测 DLCO)。结果：已建立肺气肿组的平均 ADC 和标准偏差值为 0.392 +/- 0.119 cm(2)/s，临床前肺气肿组为 0.216 +/- 0.046。已建立肺气肿组和临床前肺气肿组的MSCT值分别为：EI（%）11+/-12和0.4+/-0.6；第 15 个百分位数（亨斯菲尔德单位 (HU)）分别为 -956 +/- 25 和 -933 +/- 13，MLD (HU) 分别为 -877 +/- 20 和 -863 +/- 15。平均 ADC 与 El 和第 15 个百分位之间的相关性均为 r=0.90，MLD r=0.59。平均 ADC 与 % 预测 DLCO (r=0.90) 之间的相关性高于 El 与 % 预测 DLCO (r=0.76) 之间的相关性。结论：Hp He-3-MRI 与 MSCT 的密度测量值相关性良好，并且比 MSCT 与 % 预测 DLCO 的一致性更好，这是与肺气肿最相关的 PFT。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
Purpose: To compare apparent diffusion coefficient (ADC) measurements from hyperpolarized (HP) helium (He-3)-magnetic resonance imaging (MRI) with quantitative data from multislice Computed Tomography (CT) (MSCT) of the whole lungs and pulmonary function tests (PFT).Materials and methods: Twenty-seven subjects, 22 with established emphysema and 5 with preclinical emphysema defined by PFT criteria, were examined with Hp He-3-MRI and MSCT. Mean age was 55 (+/- 12) years, 18 female and 9 male. Mean ADC from He-3-MRI was compared with emphysema index (EI), 15th percentile and mean lung density (MLD) values from MSCT. Both mean ADC and MSCT data were compared to PFT, especially percent of predicted diffusing capacity of carbon monoxide (%predicted DLCO), using Pearson's correlation test.Results: Mean ADC and standard deviation values were 0.392 +/- 0.119 cm(2)/s for the established emphysema group and 0.216 +/- 0.046 for the pre-clinical emphysema group. MSCT values for the established emphysema group and pre-clinical emphysema group were: EI (%) 11 +/- 12 and 0.4 +/- 0.6, respectively; 15th percentile (Hounsfield Units (HU)), -956 +/- 25 and -933 +/- 13, respectively and MLD (HU) -877 +/- 20 and -863 +/- 15, respectively. Correlations between mean ADC and El and 15th percentile were both r=0.90 and for MLD r=0.59. There was higher correlation between mean ADC and %predicted DLCO (r=0.90) than between El and %predicted DLCO (r=0.76).Conclusion: Hp He-3-MRI correlates well with density measurements from MSCT and agrees better than MSCT with %predicted DLCO which is the PFT most related to emphysema. (C) 2008 Elsevier Ireland Ltd. All rights reserved.