Heavy metal poisoning and cardiovascular disease.
Heavy metal poisoning and cardiovascular disease.
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DOI：
10.1155/2011/870125
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发表时间：
2011
影响因子：
2.9
通讯作者：
Ferns GA
中科院分区：
文献类型：
--
作者：
Alissa EM;Ferns GA
心血管疾病是一个日益严重的世界性健康问题。传统的风险因素无法解释所有死于心血管疾病的人。主要是环境、饮食和生活方式的行为因素是该病进展的控制关键。慢性重金属暴露，如砷、铅、镉、汞和心血管疾病之间的潜在联系还没有很好地确定。尽管抗氧化剂代谢受损和氧化应激可能起作用，但重金属增加心血管危险因素的作用机制仍不清楚。然而，重金属诱发脑血管病的确切机制无论是通过动物实验还是通过分子和细胞研究都值得进一步研究。此外，使用适当的生物标志物和心血管终点对普通人群进行随访的大规模前瞻性研究可能被推荐，以确定在心血管疾病中易患重金属毒性的因素。在这篇综述中，我们将简要概述重金属的动态平衡，然后描述它们与心血管疾病联系的现有证据，以及可能解释其毒性效应的拟议作用机制。最后，讨论了遗传、营养和环境因素之间可能存在的相互作用。
Cardiovascular disease (CVD) is an increasing world health problem. Traditional risk factors fail to account for all deaths from CVD. It is mainly the environmental, dietary and lifestyle behavioral factors that are the control keys in the progress of this disease. The potential association between chronic heavy metal exposure, like arsenic, lead, cadmium, mercury, and CVD has been less well defined. The mechanism through which heavy metals act to increase cardiovascular risk factors may act still remains unknown, although impaired antioxidants metabolism and oxidative stress may play a role. However, the exact mechanism of CVD induced by heavy metals deserves further investigation either through animal experiments or through molecular and cellular studies. Furthermore, large-scale prospective studies with follow up on general populations using appropriate biomarkers and cardiovascular endpoints might be recommended to identify the factors that predispose to heavy metals toxicity in CVD. In this review, we will give a brief summary of heavy metals homeostasis, followed by a description of the available evidence for their link with CVD and the proposed mechanisms of action by which their toxic effects might be explained. Finally, suspected interactions between genetic, nutritional and environmental factors are discussed.