Cytogenetic abnormalities in childhood acute lymphoblastic leukemia.

Cytogenetic abnormalities in childhood acute lymphoblastic leukemia.
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儿童急性淋巴细胞白血病的细胞遗传学异常。

DOI:
10.3109/08880019309016524
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发表时间:
1993
影响因子:
1.7
通讯作者:
P. M. Ellis
P. M. Ellis
中科院分区:
医学4区
文献类型:
--
作者:
P. Micallef;O. Eden;E. Grace;P. M. Ellis

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相似文献

回顾来自同一机构的一组未经选择的急性淋巴细胞白血病患者(1981-1989)的细胞遗传学分析,证实超二倍体>50是一种有利的预后特征,而假二倍体,尤其是伴有染色体重排的假二倍体是一种不利的特征。在研究的最初几年,二倍体核型的发生率很高,但随着时间的推移(更好的显带和更密集的搜索),发生率已下降到7.7%。许多这样的患者被证明是假二倍体。分子遗传学技术正在越来越多地识别克隆异常。
A review of the cytogenetic analyses of a cohort of unselected patients with acute lymphoblastic leukemia from a single institution (1981-1989) confirmed hyperdiploidy > 50 as a favorable prognostic feature and pseudodiploidy, especially with chromosomal rearrangements, as an adverse one. In the early years of the study, a high incidence of diploid karyotype was identified, but with time (better banding and more intensive search) the incidence has fallen to 7.7%. Many such patients have been shown to be pseudodiploid. Molecular genetic techniques are increasingly identifying clonal abnormalities.
结构染色体异常对超二倍体(超过 50 条染色体)急性淋巴细胞白血病儿童的预后重要性。
DOI: --
发表时间: 1989
期刊: Blood
影响因子: 20.3
作者:
Pui,CH;Raimondi,SC;Dodge,RK;Rivera,GK;Fuchs,LA;Abromowitch,M;Look,AT;Furman,WL;Crist,WM;Williams,DL
通讯作者: Williams,DL
DOI: 10.1182/blood.v68.1.205.205
发表时间: 1986-07
期刊: Blood
影响因子: 20.3
作者:
D. Williams;J. Harber;S. Murphy;A. Look;D. Kalwinsky;G. Rivera;S. Melvin;S. Stass;G. Dahl
通讯作者: D. Williams;J. Harber;S. Murphy;A. Look;D. Kalwinsky;G. Rivera;S. Melvin;S. Stass;G. Dahl
用于治疗急性淋巴细胞白血病的直接骨髓染色体技术。
DOI: 10.1016/0165-4608(84)90046-3
发表时间: 1984
影响因子: --
作者:
Williams,DL;Harris,A;Williams,KJ;Brosius,MJ;Lemonds,W
通讯作者: Lemonds,W