Colorectal cancer-global burden, trends, and geographical variations
Colorectal cancer-global burden, trends, and geographical variations
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DOI：
10.1002/jso.24578
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发表时间：
2017-04-01
影响因子：
2.5
通讯作者：
Are, Chandrakanth
中科院分区：
文献类型：
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作者：
Douaiher, Jeffrey;Ravipati, Advaitaa;Are, Chandrakanth
背景：本研究的目的是描述结直肠癌（CRC）全球负担的趋势和变化。方法：从GLOBOCAN 2012数据库中提取2012-2030年CRC相关数据并进行分析。结果：我们的研究结果表明，全球结直肠癌负担的上升将持续到2035年，甚至可能更久。全球负担的增加并不均匀，受地理位置、社会经济地位、年龄和性别的影响存在显著差异。尽管欧洲区域的负担最重，但亚洲作为一个大陆继续承受着该疾病最严重的冲击。虽然较发达区域的疾病负担较高，但较不发达区域的死亡率要高得多，而且这一差距在今后二十年中将扩大。该疾病主要影响世界所有区域的男性。年龄与结直肠癌负担关系复杂，并受社会经济地位的交叉影响。结论：我们的研究结果表明，CRC的全球负担正在上升，但存在一些独特的差异。对这些数据的了解可以提高认识，并有助于对努力和资源进行战略性定位。
BACKGROUND: The aim of this study is to describe the trends and variations in the global burden of colorectal cancer (CRC).METHODS: Data (2012-2030) relating to CRC was extracted from GLOBOCAN 2012 database and analyzed.RESULTS: The results of our study demonstrate a rising global burden of colorectal cancer which persists until the year 2035 and likely beyond. The rise in the global burden is not uniform with significant variations influenced by geographic location, socio-economic status, age, and gender. Although the EURO region has the highest burden, Asia as a continent continues to bear the heaviest brunt of the disease. Although the burden of disease is higher in more developed regions, mortality is considerably higher in less developed regions and this gap widens over the next two decades. The disease predominantly affects the male gender across all regions of the world. Age has a complex relation with the burden of CRC and is affected by the cross-influences relating to socio-economic status.CONCLUSIONS: The results of our study demonstrate a rising global burden of CRC with some unique variations. Knowledge of this data can increase awareness and help strategic targeting of efforts and resources.