When Physics Takes Over: BAR Proteins and Membrane Curvature.
When Physics Takes Over: BAR Proteins and Membrane Curvature.
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DOI：
10.1016/j.tcb.2015.09.005
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发表时间：
2015-12
影响因子：
19
通讯作者：
Bassereau P
中科院分区：
文献类型：
--
作者：
Simunovic M;Voth GA;Callan-Jones A;Bassereau P
在膜运输、胞质分裂、感染、免疫反应或细胞运动过程中，细胞膜变得高度弯曲。 Bin/amphiphyn/Rvs (BAR) 结构域蛋白具有本质上弯曲和各向异性的形状，参与了许多这些过程，但具有多种作用模式。体外实验和多尺度计算机模拟有助于确定一组最小的物理参数，即膜上的蛋白质密度、膜张力和膜形状，这些参数控制着结合的 BAR 结构域蛋白在膜上的行为。在这篇综述中，我们总结了 BAR 蛋白与膜力学的多方面耦合，并提出了一个简单的相图来概括这些参数的影响。
Cell membranes become highly curved during membrane trafficking, cytokinesis, infection, immune response or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their intrinsically curved and anisotropic shape are involved in many of these processes, but with a large spectrum of modes of action. In vitro experiments and multiscale computer simulations have contributed in identifying a minimal set of physical parameters, namely protein density on the membrane, membrane tension, and membrane shape, that control how bound BAR domain proteins behave on the membrane. In this review, we summarize the multifaceted coupling of BAR proteins to membrane mechanics and propose a simple phase diagram that recapitulates the effects of these parameters.