Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway.
Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway.
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DOI：
10.3892/ol.2016.4928
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发表时间：
2016-10
期刊：
影响因子：
2.9
通讯作者：
Wen Zheng;Shiliu Lu;Haolei Cai;Muxing Kang;W. Qin;Chao Li;Yulian Wu
中科院分区：
文献类型：
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作者：
Wen Zheng;Shiliu Lu;Haolei Cai;Muxing Kang;W. Qin;Chao Li;Yulian Wu
胰腺癌是一种高致死性的恶性肿瘤，目前治疗方法尚不多见。鱼藤素是类黄酮家族的天然化合物，据报道对多种癌症具有抑制作用。在本研究中，我们调查鱼藤素是否有抗肿瘤疗效的PC。鱼藤素处理被观察到在两个PC细胞系（Bxpc-3和Panc-1）中抑制生长并诱导凋亡。此外，它还抑制了这两种细胞系的迁移和侵袭。刺猬（Hh）信号通路的激活，以及基质金属蛋白酶（MMP）-2和MMP-9，被鱼藤素抑制。这些结果表明，鱼藤素可能是一个潜在的化疗剂PC，可能通过抑制Hh信号通路。
Pancreatic cancer (PC) is a highly lethal malignancy with few effective therapies. Deguelin, a natural compound of the flavonoid family of products, has been reported to have an inhibitory effect on various cancers. In the present study, we investigated whether deguelin had antitumor efficacy in PC. Deguelin treatment was observed to inhibit growth and induce apoptosis in two PC cell lines (Bxpc-3 and Panc-1). In addition, it inhibited migration and invasion in these two cell lines. The activation of the hedgehog (Hh) signaling pathway, as well as matrix metalloproteinases (MMP)-2 and MMP-9, was suppressed by deguelin. These results suggest that deguelin may be a potential chemotherapeutic agent for PC, possibly through the suppression of the Hh signaling pathway.