Effects of light variation on Schwalbe's line-based anterior chamber angle metrics measured with cirrus spectral domain optical coherence tomography
Effects of light variation on Schwalbe's line-based anterior chamber angle metrics measured with cirrus spectral domain optical coherence tomography
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DOI：
10.1111/ceo.12700
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发表时间：
2016-08-01
影响因子：
4
通讯作者：
Chopra, Vikas
中科院分区：
文献类型：
--
作者：
Marion, Kenneth M.;Niemeyer, Moritz;Chopra, Vikas
背景使用光谱域光学相干断层扫描(SD-OCT)评估环境照明条件的变化对基于Schwalbe‘s Line(SL)的前房角(ACA)测量的重复性/可靠性的影响。设计图像由Doheny眼科中心-UCLA诊所拍摄，随机，参与者25名正常/健康受试者的角度是开放的。方法使用Cirrus SD-OCT在五种光线水平(用Sper测光仪在相机-眼睛界面测量的足烛光(FC))下对干涉角度进行成像，仪器的角膜照明功能设置为默认水平50(CIdef)和低5(CIlow)。对每只眼进行20次成像，共计500次评估。主要结果测量SL角开放距离(SL-AOD)和SL-小梁虹膜空间面积(SL-TISA)使用定制的ImageJ软件测量。利用社会科学统计包和Bland-Altman图进行年级内/年级间的变异分析。结果光照水平与角度大小呈线性关系，从而比较了最高光照水平和最低光照水平之间的差异。在CIdef从1.00.0fc开始的减光使SL-AOD从394微米+/-137微米下降到356微米+/-137微米(平均百分比差异(MPD)=10.71%，P
BackgroundEvaluate the impact of variations in ambient lighting conditions on the reproducibility/reliability of Schwalbe's Line (SL)-based anterior chamber angle (ACA) metrics using spectral domain optical coherence tomography (SD-OCT).DesignImages were taken at Doheny Eye Centers-UCLA clinic, which were randomized, masked and graded twice by dual reading centre graders.ParticipantsTwenty-five normal/healthy participants with open anglesMethodsInferior angles were imaged using Cirrus SD-OCT under five light levels (foot-candles (fc) measured at camera-eye interface with Sper light-meter) with the instrument's corneal illumination function set to default level of 50 (CIdef) and low 5 (CIlow). Each eye was imaged 20 times, totaling 500 assessments.Main Outcome MeasuresSL-angle-opening-distance (SL-AOD) and SL-trabecular-iris-space-area (SL-TISA) measured using custom ImageJ software. Intra-/inter-grader variability analyses were completed using Statistical-Package-for-Social-Science and Bland-Altman plots demonstrated limits of agreement for comparisons.ResultsLight level demonstrated a linear relationship with angle size, thus differences from highest to lowest light levels were compared. Decreasing light from 1.00.0fc at CIdef decreased SL-AOD from 394 mu m+/-137 mu m356 mu m+/-137 mu m (mean percent difference (MPD)=10.71%,P