Non-invasive imaging of single human motor units
Non-invasive imaging of single human motor units
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DOI：
10.1016/j.clinph.2020.02.004
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发表时间：
2020-06-01
影响因子：
4.7
通讯作者：
Whittaker, Roger G.
中科院分区：
文献类型：
--
作者：
Birkbeck, Matthew G.;Heskamp, Linda;Whittaker, Roger G.
Objectives to determine the size，shape and distribution of single human motor units in vivo in healthy controls different age.MethodsA novel diffusion-weighted magnetic resonance imaging（MRI）technique was used in combination with in-scanner electrical stimulation to quantify the shape，cross-sectional area，and dimensions of individual motor units in 10 healthy subjects.Results31 discrete motor units were studied.大多数为椭圆形或新月形，但偶尔观察到分裂的运动单位。平均运动单位横截面积为26.7 +/- 11.2 mm（2），平均最大尺寸为10.7 +/- 3.3 mm，平均最小尺寸为4.5 ± 1.2 mm。40岁以上受试者的最大尺寸显著大于40岁以下受试者结论运动单位磁共振成像（MUMRI）是一种能够显示人体肌肉多个运动单位的大小、形态和位置的新技术。它是可重复的，非侵入性的，和足够的敏感性，以检测生理相关的变化，运动单位形态与age.SignificanceTo我们的知识，这些结果提供了第一次成像评估人类运动单位形态。该技术显示出作为诊断工具和作为疾病进展纵向研究中的生物标志物的前景。
ObjectiveTo determine the size, shape and distribution of single human motor units in-vivo in healthy controls of different ages.MethodsA novel diffusion-weighted magnetic resonance imaging (MRI) technique was used in combination with in-scanner electrical stimulation to quantify the shape, cross-sectional area, and dimensions of individual motor units in 10 healthy subjects.ResultsThirty-one discrete motor units were studied. The majority were elliptical or crescent shaped, but occasional split motor units were observed. The mean motor unit cross sectional area was 26.7 +/- 11.2 mm(2), the mean maximum dimension was 10.7 +/- 3.3 mm, and the mean minimum dimension was 4.5 +/- 1.2 mm. Subjects aged over 40 had significantly larger maximum dimensions than those below this age (p < 0.05).ConclusionsMotor unit MRI (MUMRI) is a novel technique capable of revealing the size, shape and position of multiple motor units in human muscles. It is reproducible, non-invasive, and sufficiently sensitive to detect physiologically relevant changes in motor unit morphology with age.SignificanceTo our knowledge, these results provide the first imaging assessment of human motor unit morphology. The technique shows promise both as a diagnostic tool and as a biomarker in longitudinal studies of disease progression.