γ chain required for naive CD4+ T cell survival but not for antigen proliferation
γ chain required for naive CD4+ T cell survival but not for antigen proliferation
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DOI：
10.1038/76917
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发表时间：
2000-07-01
影响因子：
30.5
通讯作者：
Di Santo, JP
中科院分区：
文献类型：
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作者：
Lantz, O;Grandjean, I;Di Santo, JP
因此，免疫系统必须维持能够对新抗原应答的幼稚T细胞以及对其已经遇到的那些抗原特异性的记忆T细胞的不同群体。尽管幼稚T细胞和记忆T细胞都驻留在次级淋巴器官中并通过次级淋巴器官运输，越来越多的证据表明，这两个群体可能受到不同的调节，我们在这里表明，幼稚T细胞存活和记忆T细胞存活对细胞因子有不同的要求（包括白细胞介素IL-2、IL-4、IL-7、IL-9和IL-15），其使用共同的细胞因子受体γ链（γ（c））。使用抗原特异性CD 4（+）T细胞的单克隆群体，我们发现初始T细胞不能在没有γ（c）的情况下存活，而记忆T细胞则没有这种要求。与此相反，无论是幼稚还是γ（c）缺陷型记忆T细胞在体内抗原刺激下增殖和产生细胞因子的能力均未受损。这些数据对γ（c）依赖性细胞因子作为T细胞生长因子的生理作用提出了质疑，并表明幼稚和记忆CD 4（+）T细胞的存活是通过不同的机制维持的。
Lymphoid homeostasis is required to ensure immune responsiveness and to prevent immunodeficiency, As such, the immune system must maintain distinct populations of naive T cells that are able to respond to new antigens as well as memory T cells specific to those antigens it has already encountered,Though both naive and memory T cells reside in and traffic through secondary lymphoid organs, there is growing evidence that the two populations may be regulated differently,We show here that naive T cell survival and memory T cell survival have different requirements for cytokines (including the interleukins IL-2, IL-4, IL-7, IL-9 and IL-15) that use the common cytokine receptor gamma chain (gamma(c)). Using monoclonal populations of antigen-specific CD4(+) T cells, we found that naive T cells cannot survive without gamma(c), whereas memory T cells show no such requirement. In contrast, neither naive nor gamma(c)-deficient memory T cells were impaired in their ability to proliferate and produce cytokines in response to in vivo antigenic stimulation,These data call into question the physiological role of gamma(c)-dependent cytokines as T cell growth factors and show that naive and memory CD4(+)T cell survival is maintained by distinct mechanisms.