The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development
The gene pair PRR11 and SKA2 shares a NF-Y-regulated bidirectional promoter and contributes to lung cancer development
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基因对 PRR11 和 SKA2 共享一个 NF-Y 调节的双向启动子，并有助于肺癌的发展。
DOI：
10.1016/j.bbagrm.2015.07.002
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发表时间：
2015-09-01
影响因子：
4.7
通讯作者：
Bu, Youquan
中科院分区：
文献类型：
--
作者：
Wang, Yitao;Zhang, Ying;Bu, Youquan
头对头基因对代表了真核生物中基因组织的独特特征，占人类基因组中基因的>10%。这些基因对的鉴定和功能分析还处于起步阶段。最近，我们发现PRR 11是一种新的癌症相关基因，与细胞周期和肺癌有关。在这里，我们证明PRR 11是在一个头对头的配置与其相邻的基因，SKA 2的方向。5 '-RACE分析表明，两个基因之间的基因间隔区，
Head-to-head gene pairs represent a unique feature of gene organization in eukaryotes, accounting for >10% of genes in the human genome. Identification and functional analysis of such gene pairs is only in its infancy. Recently, we identified PRR11 as a novel cancer-related gene that is implicated in cell cycle and lung cancer. Here we demonstrate that PRR11 is oriented in a head-to-head configuration with its neighboring gene, SKA2. 5'-RACE assay revealed that the intergenic spacer region between the two genes is