Nonspecific interstitial pneumonitis: a common cause of pulmonary disease in the acquired immunodeficiency syndrome.
Nonspecific interstitial pneumonitis: a common cause of pulmonary disease in the acquired immunodeficiency syndrome.
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非特异性间质性肺炎：获得性免疫缺陷综合征中肺部疾病的常见原因。
DOI：
10.7326/0003-4819-107-1-7
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发表时间：
1987
影响因子：
39.2
通讯作者：
J. Shelhamer
中科院分区：
文献类型：
--
作者：
A. Suffredini;F. Ognibene;E. Lack;J. T. Simmons;M. Brenner;V. Gill;H. Lane;A. Fauci;J. Parrillo;H. Masur;J. Shelhamer
在4.4年的研究期间，110例获得性免疫缺陷综合征患者中有41例（38%）出现非特异性间质性肺炎，占所有临床肺炎发作的32%（48/152）。弥漫性肺泡损伤是非特异性间质性肺炎的典型特征，但肺活检和支气管肺泡灌洗均未检出病原体。在这41例患者中，13例没有相关的肺肿瘤，也没有暴露于肺毒素，而28例患者同时患有肺卡波西肉瘤，既往的实验性治疗，或肺囊虫肺炎或药物滥用史。在这41人中，23人胸片正常。非特异性间质性肺炎患者的临床特征与肺囊虫性肺炎患者相似，尽管组织学结果显示非特异性间质性肺炎患者的肺泡损伤较轻（p < 0.001）。病理评估和临床随访提示，许多获得性免疫缺陷综合征患者的肺炎临床发作是由于不明原因的非特异性间质性肺炎。
During a 4.4-year period, nonspecific interstitial pneumonitis was seen in 41 of 110 (38%) patients with the acquired immunodeficiency syndrome and accounted for 32% (48/152) of all episodes of clinical pneumonitis. Diffuse alveolar damage was typically a feature of nonspecific interstitial pneumonitis, but neither lung biopsy nor bronchoalveolar lavage detected a pathogen. Of these 41 patients, 13 had no associated pulmonary tumor and had not been exposed to pulmonary toxins, whereas 28 patients had either concurrent pulmonary Kaposi sarcoma, previous experimental therapies, or a history of pneumocystis pneumonia or drug abuse. Of these 41, 23 had normal chest radiographs. The clinical features of patients with nonspecific interstitial pneumonitis were similar to those of patients with pneumocystis pneumonia, although histologic findings showed less severe alveolar damage in patients with nonspecific interstitial pneumonitis (p less than 0.001). Pathologic evaluation and clinical follow-up suggest that many clinical episodes of pneumonitis in patients with the acquired immunodeficiency syndrome are due to nonspecific interstitial pneumonitis of unknown cause.