The development of SERI® Surgical Scaffold, an engineered biological scaffold
The development of SERI® Surgical Scaffold, an engineered biological scaffold
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DOI：
10.1111/nyas.12886
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Mortarino, Enrico
中科院分区：
文献类型：
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作者：
Jewell, Mark;Daunch, William;Mortarino, Enrico
重建和翻修手术的主要目标是恢复、修复、重建和支持受损、弱化或缺失的组织。存在许多用于软组织支撑和修复的方法，包括使用自体组织、人或动物来源的脱细胞真皮基质、可吸收或永久性合成网片，以及现在的一类新的生物可吸收蛋白质支架。尽管许多因素会影响手术入路的选择以及用于软组织支撑和修复的特定产品，但目标是改善长期结局，同时最大限度地减少需要进一步翻修手术的并发症和复发。在这篇综述中，SERI外科支架，一种新型的，工程化的，高纯度的软组织支持和修复的丝绸产品的基础科学，临床特点和临床应用将被提出。
The primary goal of reconstructive and revision surgery is to restore, repair, rebuild, and support damaged, weakened, or absent tissue. There are numerous approaches for soft tissue support and repair, including the use of autologous tissue, human- or animal -derived acellular dermal matrices, absorbable or permanent synthetic mesh, and, now, a new class of bioresorbable protein scaffold. Although many factors influence the choice of surgical approach and the specific product used for soft tissue support and repair, the goal is to improve long-term outcomes while minimizing complications and recurrences requiring further revisional surgery. In this review, the basic science, clinical characteristics, and clinical applications of SERI Surgical Scaffold, a novel, engineered, highly purified silk product for soft tissue support and repair will be presented.