The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
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发表时间：
1978
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通讯作者：
R. Schofield
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作者：
R. Schofield
本文综述了与脾集落形成细胞（CFU-S）是主要造血干细胞的观点不一致的几个实验结果。CFU-S的定量和定性回收可以根据用于引起消耗的细胞毒性剂或方案而不同地进行。干细胞群体的虚拟永生与CFU-S群体具有“年龄结构”的证据不一致，该证据已被几位工作人员引用来解释实验和临床观察。为了解释这些不一致，提出了一个假设，其中干细胞与决定其行为的其他细胞相关联。它基本上变成了一个固定的组织细胞。它的成熟被阻止，因此，它作为干细胞的持续增殖得到保证。除非它们能够占据类似的干细胞“生态位”，否则其后代是第一代集落形成细胞，其增殖并成熟以获得高分化概率，即，他们有年龄结构。一些实验的情况进行了讨论，在有关建议的假设。
Several experimental findings that are inconsistent with the view that the spleen colony-forming cell (CFU-S) is the primary haemopoietic stem cell are reviewed. Recovery of CFU-S, both quantitatively and qualitatively, can proceed differently depending upon the cytotoxic agent or regime used to bring about the depletion. The virtual immortality of the stem cell population is at variance with evidence that the CFU-S population has an 'age-structure' which has been invoked by several workers to explain experimental and clinical observations. To account for these inconsistencies, a hypothesis is proposed in which the stem cell is seen in association with other cells which determine its behaviour. It becomes essentially a fixed tissue cell. Its maturation is prevented and, as a result, its continued proliferation as a stem cell is assured. Its progeny, unless they can occupy a similar stem cell 'niche', are first generation colony-forming cells, which proliferate and mature to acquire a high probability of differentiation, i.e., they have an age-structure. Some of the experimental situations reviewed are discussed in relation to the proposed hypothesis.