Effect of smoking on binding of lidocaine to human serum proteins.
Effect of smoking on binding of lidocaine to human serum proteins.
复制标题
吸烟对利多卡因与人血清蛋白结合的影响。
DOI：
10.1002/jps.2600690646
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发表时间：
1980
影响因子：
3.8
通讯作者：
Lalka,D
中科院分区：
文献类型：
--
作者：
McNamara,PJ;Slaughter,RL;Visco,JP;Elwood,CM;Siegel,JH;Lalka,D
在1978年8月14日的USP XX注释证明（第3卷，第56号）中公布了胶囊的拟定崩解时限检测方法。该程序基于药品制造商协会（PMA）质量控制部门崩解时限检查审查委员会进行的一系列合作研究。美国药典和美国国家处方集描述了五种片剂的崩解时限试验。PMA项目旨在使用片剂崩解装置和方法开发硬明胶胶囊产品的类似试验，必要时变更较少。研究中使用了3份供试品（含0.5、1.0和1.5%硬脂酸镁乳糖溶液的2号硬明胶胶囊），以评价程序变量。对每个变量的评论如下。
A proposed disintegration test procedure for capsules was published in the USP XX Comment Proof (Vol. 3, No. 56) dated August 14, 1978. This procedure was based on a series of collaborative studies conducted by the Disintegration Test Review Committee of the Pharmaceutical Manufacturers Association (PMA) Quality Control Section. Highlights of these studies are presented in this communication.The USP and NF describe disintegration tests for five tablet categories. The PMA project was aimed at developing a similar test for hard gelatin capsule produds using the apparatus and methodology for tablet disintegration with as few changes as necessary. Three test samples (No. 2 hard gelatin capsules containing 0.5, 1.0, and 1.5% magnesium stearate in lactose) were used in the studies to evaluate procedure variables. Comments on each variable follow.