Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero.
Associations of infant milk feed type on early postnatal growth of offspring exposed and unexposed to gestational diabetes in utero.
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DOI：
10.1007/s00394-015-1057-0
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发表时间：
2017-02
影响因子：
5
通讯作者：
Lee YS
中科院分区：
文献类型：
--
作者：
Aris IM;Soh SE;Tint MT;Saw SM;Rajadurai VS;Godfrey KM;Gluckman PD;Yap F;Chong YS;Lee YS
众所周知，长时间母乳喂养的婴儿在生命的第一年生长较慢。目前尚不清楚在子宫内暴露于妊娠期糖尿病(GDM)的后代是否存在类似的影响。在暴露于GDM和未暴露于GDM的后代中，我们研究了婴儿母乳喂养对从出生到36个月大的出生后生长的关系。孕妇在怀孕26-28周进行75 mg 2小时口服葡萄糖耐量测试，以诊断GDM。从出生到36个月，收集了多达9个孩子的体重和身高测量数据，并使用面试者管理的问卷来确定母乳喂养的持续时间。在有条件体重增加的结果中，妊娠期糖尿病状态与母乳摄入量之间存在统计学意义的交互作用(p交互作用=0.038)或纯母乳喂养/主要母乳喂养(p交互作用t=0.035)。在非妊娠期糖尿病母亲的子女(n=835)中，较多的母乳摄入量(BF和≥4个月)与出生一年内体重[B(95%CI)−0.48(−0.58，−0.28)；P<0.001]以及体重下降的SDs速度[−0.008(−0.02，−0.005)；P<0.001]和BMI SD速度[−0.008(0.01，−0.002)]相关；P=0.008]前36个月不同年龄段。然而，在妊娠期糖尿病母亲的子女(n=8181)中，在前6个月中，母乳摄入量的增加与体重[0.72(0.23，1.2)；p=0.029]和体重指数抑郁[0.49(0.04，0.95)；p=0.04]的增加相关，并且没有显示出非妊娠期糖尿病母亲的子女体重和体重指数抑郁速度的下降。在妊娠期糖尿病儿童中，非妊娠期糖尿病儿童通过增加母乳摄入量而导致的出生第一年体重增加的减少并未观察到。这项研究是在临床试验识别号NCT01174875下注册的；http://www.clinicaltrials.gov/ct2/show/NCT01174875?term=GUSTO&rank=2.本文的在线版本(DOI：10.1007/s00394-0151057-0)包含补充材料，授权用户可以获得。
Infants on prolonged breastfeeding are known to grow slower during the first year of life. It is still unclear if such effects are similar in offspring exposed to gestational diabetes (GDM) in utero. We examined the associations of infant milk feeding on postnatal growth from birth till 36 months of age in offspring exposed and unexposed to GDM. Pregnant mothers undertook 75 g 2-h oral glucose tolerance tests at 26–28 weeks of gestation for GDM diagnosis. Up to 9 measurements of offspring weight and length were collected from birth till 36 months, and interviewer-administered questionnaires were used to ascertain the duration of breastfeeding. There was a statistically significant interaction between GDM status and breastmilk intake by any (p interaction = 0.038) or exclusive/predominant breastfeeding (p interaction = 0.035) for the outcome of conditional weight gain. In offspring of non-GDM mothers (n = 835), greater breastmilk intake (BF ≥ 4 milk months) was associated with lower conditional gains in weight [B (95 % CI) −0.48 (−0.58, −0.28); p < 0.001] within the first year of life, as well as decreasing weight SDS velocity [−0.01 (−0.02, −0.005); p < 0.001] and BMI SDS velocity [−0.008 (0.01, −0.002); p = 0.008] across age in the first 36 months. In offspring of GDM mothers (n = 181), however, greater breastmilk intake was associated with increased conditional gains in weight [0.72 (0.23, 1.20); p = 0.029] and BMI SDS [0.49 (0.04, 0.95); p = 0.04] in the first 6 months and did not demonstrate the decreasing weight and BMI SDS velocity observed in offspring of non-GDM mothers. The reduced weight gain in the first year of life conferred by greater breastmilk intake in non-GDM children was not observed in GDM children. This study is registered under the Clinical Trials identifier NCT01174875; http://www.clinicaltrials.gov/ct2/show/NCT01174875?term=GUSTO&rank=2. The online version of this article (doi:10.1007/s00394-015-1057-0) contains supplementary material, which is available to authorized users.