Immunological evaluation and cellular location analysis of the TprI antigen of Treponema pallidum subsp pallidum
Immunological evaluation and cellular location analysis of the TprI antigen of Treponema pallidum subsp pallidum
复制标题
DOI：
10.1128/iai.73.6.3817-3822.2005
复制
发表时间：
2005-06-01
影响因子：
3.1
通讯作者：
Cevenini, R
中科院分区：
文献类型：
--
作者：
Giacani, L;Sambri, V;Cevenini, R
梅毒螺旋体TprI抗原。梅毒螺旋体是一种推定的毒力因子，预计位于梅毒螺旋体的外膜上。在这项研究中，我们分析了对TprI及其亚基的免疫反应，从实验感染的尼科尔斯菌株的兔子和梅毒患者的血清中收集，显示了不同的模式对抗原的反应，在这两组样品。还研究了重组TprI的保护能力及其假设的外膜位置。虽然没有兔子被保护后的挑战，免疫电镜结果，有待进一步研究，是兼容的外膜位置的抗原。
The TprI antigen of Treponema pallidum subsp. pallidum is a putative virulence factor predicted to be located in the outer membrane of the syphilis spirochete. In this study, we analyzed the immune response against TprI and its subunits in sera collected both from rabbits experimentally infected with the Nichols strain and from patients with syphilis, showing a different pattern of reactivity toward the antigen in these two groups of samples. The protective ability of recombinant TprI and its hypothetical outer membrane location were also investigated. Although no rabbit was protected after challenge, immunoelectron microscopy results, to be further investigated, were compatible with the outer membrane location of the antigen.