Endoscopic comparison of three aspirin preparations and placebo.
Endoscopic comparison of three aspirin preparations and placebo.
复制标题
三种阿司匹林制剂和安慰剂的内窥镜比较。
作者：
D. Petroski
84名年龄在22至70岁之间的志愿者中，有80人成功完成了一项为期3个月的单盲内窥镜研究，他们接受了单剂量安慰剂或325毫克/天的肠溶阿司匹林（ECA）、缓冲阿司匹林（BA）或普通阿司匹林（ASA）。在研究开始时、4周、8周和12周后进行上腔镜检查。采用Lanza等人改良的系统对胃和十二指肠粘膜进行内窥镜评分。肠溶阿司匹林和安慰剂在胃损伤方面没有统计学差异，但两者与ASA和BA有显著差异。ASA和BA对胃粘膜均有明显损伤，两者无显著性差异。对十二指肠黏膜损伤的分析显示，BA、ECA、ASA和安慰剂组之间无显著性差异。此外，年龄与损伤之间的统计关系也无法得到证实。
Eighty of 84 volunteers aged 22 to 70 years successfully completed a 3-month, single-blind endoscopic study in which they received single-dose placebo or 325 mg/day of enteric-coated aspirin (ECA), buffered aspirin (BA), or plain aspirin (ASA). Upper endoscopy was performed at the beginning of the study and after 4, 8, and 12 weeks. The gastric and duodenal mucosa was scored endoscopically using a system adapted from Lanza et al. Enteric-coated aspirin and placebo were not statistically different from one another in the gastric damage produced, but both were significantly different from ASA and BA. Significant damage to the gastric mucosa was seen with ASA and BA, with no significant difference between them. Analysis of duodenal mucosa injury revealed that BA, ECA, ASA, and placebo were not significantly different from one another. In addition, a statistical relationship between age and injury could not be proven.