Dynamics of auditory-vocal interaction in monkey auditory cortex
Dynamics of auditory-vocal interaction in monkey auditory cortex
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DOI：
10.1093/cercor/bhi030
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发表时间：
2005-10-01
期刊：
影响因子：
3.7
通讯作者：
Wang, XQ
中科院分区：
文献类型：
--
作者：
Eliades, SJ;Wang, XQ
灵长类听觉皮层的单个神经元在自发发声过程中表现出与发声相关的调制（兴奋性或抑制性）。先前的研究表明，这些皮层活动的调制在个体神经元对多个发声实例的反应中是可变的，并且在不同的皮层神经元之间是不同的。本研究探讨了发声相关调制的动态模式，并证明了皮质调制的变异性与自发发声的声学结构有关。我们发现，在多短语的发声过程中，单个单位活动的抑制是时间特异性的，因为它是在每个短语中保持，但在短语之间释放。此外，抑制或激发的程度与所产生的发声的平均能量和频率相关，占多个发声实例之间的响应变异性的很大一部分。从一个单一的电极对神经元的同时记录显示，调制附近的神经元自发发声在很大程度上是不相关的。此外，发声引起的抑制被认为是优先分布到上皮层。最后，我们发现，发声过程中所有听觉皮层活动的总和，包括单个和多个单位的反应，是弱兴奋性的，与人类大脑在讲话过程中的研究观察结果一致。
Single neurons in the primate auditory cortex exhibit vocalization-related modulations (excitatory or inhibitory) during self-initiated vocal production. Previous studies have shown that these modulations of cortical activity are variable in individual neurons' responses to multiple instances of vocalization and diverse between different cortical neurons. The present study investigated dynamic patterns of vocalization-related modulations and demonstrated that much of the variability in cortical modulations was related to the acoustic structures of self-produced vocalization. We found that suppression of single unit activity during multi-phrased vocalizations was temporally specific in that it was maintained during each phrase, but was released between phrases. Furthermore, the degree of suppression or excitation was correlated to the mean energy and frequency of the produced vocalizations, accounting for much of the response variability between multiple instances of vocalization. Simultaneous recordings of pairs of neurons from a single electrode revealed that the modulations by self-produced vocalizations in nearby neurons were largely uncorrelated. Additionally, vocalization-induced suppression was found to be preferentially distributed to upper cortical layers. Finally, we showed that the summation of all auditory cortical activity during vocalization, including both single and multi-unit responses, was weakly excitatory, consistent with observations from studies of the human brain during speech.