Bignanoside A "A new neolignan glucoside" and bignanoside B "A new iridoid glucoside" from Bignonia binata leaves
Bignanoside A "A new neolignan glucoside" and bignanoside B "A new iridoid glucoside" from Bignonia binata leaves
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DOI：
10.1016/j.phytol.2019.12.009
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发表时间：
2020-02-01
影响因子：
1.7
通讯作者：
Kamel, Mohamed Salah
中科院分区：
文献类型：
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作者：
Mahmoud, Basma Khalaf;Samy, Mamdouh Nabil;Kamel, Mohamed Salah
一个新的新木脂素葡萄糖苷;从紫藤叶中分离得到7个化合物，其中紫藤苷A（1）和一个新的环烯醚萜苷，紫藤苷B（2）和一个新的木脂素鼠李糖苷，（-）-1约尼树脂醇3 α-O-α-L-吡喃鼠李糖苷（3）为首次报道。化合物2具有较强的DPPH自由基清除活性，其IC 50值为18.34 +/- 0.81 μ M。同样，化合物4和9显示出抗锥虫活性，其对布氏锥虫S427的IC 50值分别为29.12 +/-1.21和17.80 +/-0.32 μ M。
One new neolignan glucoside; bignanoside A (1) and one new iridoid glucoside; bignanoside B (2), and one new lignan rhamnoside; (-)-1yoniresinol 3 alpha-O-alpha-L-rhamnopyranoside (3) reported for the first time, alongside with seven known compounds were isolated from Bignonia binata leaves. The structures of the isolated compounds were elucidated by various spectroscopic methods, including 1D and 2D NMR experiments, as well as HR-ESI-MS. Compound 2 had a potent DPPH radical scavenging activity with IC50, value of 18.34 +/- 0.81 mu M. Likewise, compounds 4 and 9 exhibited antitrypanosomal activity with IC50, value of 29.12 +/- 1.21 and 17.80 +/- 0.32 mu M, respectively, against Trypanosoma brucei brucei S427.