Effects of reproductive status on behavioral and neural responses to isolated pup stimuli in female California mice
Effects of reproductive status on behavioral and neural responses to isolated pup stimuli in female California mice
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DOI：
10.1016/j.bbr.2023.114727
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发表时间：
2023-10-28
影响因子：
2.7
通讯作者：
Saltzman，Wendy
中科院分区：
文献类型：
--
作者：
Wilson，Kerianne M.;Arquilla，April M.;Saltzman，Wendy
哺乳动物向母性的转变以雌性对来自婴儿的感觉刺激的感知和反应的变化为标志。我们对母体诱导的感觉可塑性的理解在很大程度上依赖于对单亲、杂交家鼠和大鼠的研究，这些研究可能不能代表具有不同生活史的啮齿动物物种。我们让双亲、一夫一妻制的加州小鼠(Permyscus CalforNicus)的母亲和去卵巢的处女受到四种声学和嗅觉刺激组合中的一种(对照：干净的棉花和白噪音；Call：干净的棉花和幼崽的发声；气味：小狗气味的棉花和白噪音；Call+Odor：小狗气味的棉花和小狗发声)，并量化雌性动物的行为和Fos在选定大脑区域的表达。母亲和切除卵巢的处女之间的行为没有区别。然而，在母亲中，那些暴露在控制条件下的母亲嗅到气味刺激的时间最长，而暴露在气味条件下的母亲比那些处于通话条件下的母亲闻到气味球的速度更快。暴露在不同条件下的卵巢切除处女之间的行为没有差异。Fos的表达在不同的条件下只在对厌恶刺激做出反应的下丘脑前核(Ahn)中有所不同：在母亲中，Control条件下的Ahn Fos表达最高，Call+Odor条件下的Ahn Fos表达最低。在去卵巢的处女中，CALL引起的Fos在Ahn中最低。因此，加利福尼亚老鼠的生殖状态改变了雌性老鼠对幼崽刺激的行为反应，特别是气味，并导致对幼崽刺激反应的防御回路的抑制。
The transition to motherhood in mammals is marked by changes in females’ perception of and responsiveness to sensory stimuli from infants. Our understanding of maternally induced sensory plasticity relies most heavily on studies in uniparental, promiscuous house mice and rats, which may not be representative of rodent species with different life histories. We exposed biparental, monogamous California mouse (Peromyscus californicus) mothers and ovariectomized virgin females to one of four acoustic and olfactory stimulus combinations (Control: clean cotton and white noise; Call: clean cotton and pup vocalizations; Odor: pup-scented cotton and white noise; Call + Odor: pup-scented cotton and pup vocalizations) and quantified females’ behavior and Fos expression in select brain regions. Behavior did not differ between mothers and ovariectomized virgins. Among mothers, however, those exposed to the Control condition took the longest to sniff the odor stimulus, and mothers exposed to the Odor condition were quicker to sniff the odor ball compared to those in the Call condition. Behavior did not differ among ovariectomized virgins exposed to the different conditions. Fos expression differed across conditions only in the anterior hypothalamic nucleus (AHN), which responds to aversive stimuli: among mothers, the Control condition elicited the highest AHN Fos and Call + Odor elicited the lowest. Among ovariectomized virgin females, Call elicited the lowest Fos in the AHN. Thus, reproductive status in California mice alters females’ behavioral responses to stimuli from pups, especially odors, and results in the inhibition of defense circuitry in response to pup stimuli.