Prevotella copri in individuals at risk for rheumatoid arthritis
Prevotella copri in individuals at risk for rheumatoid arthritis
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DOI：
10.1136/annrheumdis-2018-214514
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发表时间：
2019-05-01
影响因子：
27.4
通讯作者：
Strowig, Till
中科院分区：
文献类型：
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作者：
Alpizar-Rodriguez, Deshire;Lesker, Till Robin;Strowig, Till
目的类风湿性关节炎(RA)与粪便普氏杆菌的相对扩张有关。目的了解普氏杆菌的微生物群组成及流行情况。方法在一项对RA患者的一级亲属(FDR)进行的队列研究中，我们确定了无症状和没有自身抗体的FDR对照组，以及临床前RA阶段的患者，他们要么发展了抗硝酸肽抗体，要么出现了类风湿因子阳性和/或与可能的RA相关的症状和体征。结果共纳入133名受试者，其中50人为FDR对照组，83人为临床前RA阶段。与FDR对照组相比，处于临床前RA阶段的个体的微生物区系发生了显著变化。在临床前RA组中发现普氏杆菌科细菌，尤其是普雷沃特氏菌有显著的丰富(p=0.04)。在RA临床前阶段的个体中，在RA发病之前，提示肠道生态失调在RA的发展中起着作用。
Objectives Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of Prevotella spp. in a group of individuals at increased risk for RA, but prior to the development of the disease.Methods I n an ongoing cohort study of first-degree relatives (FDRs) of patients with RA, we identified 'FDR controls', asymptomatic and without autoantibodies, and individuals in pre-clinical RA stages, who had either developed anticitrullinated peptide antibodies or rheumatoid factor positivity and/ or symptoms and signs associated with possible RA. Stool sampling and culture-independent microbiota analyses were performed followed by descriptive statistics and statistical analyses of community structures.Results A total of 133 participants were included, of which 50 were categorised as 'FDR controls' and 83 in 'pre-clinical RA stages'. The microbiota of individuals in 'pre-clinical RA stages' was significantly altered compared with FDR controls. We found a significant enrichment of the bacterial family Prevotellaceae, particularly Prevotella spp., in the 'pre-clinical RA' group (p=0.04).Conclusions Prevotella spp. enrichment in individuals in pre-clinical stages of RA, before the onset of RA, suggests a role of intestinal dysbiosis in the development of RA.