Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study
Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study
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DOI：
10.1016/s2214-109x(19)30070-1
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发表时间：
2019-05-01
影响因子：
34.3
通讯作者：
Yusuf, Salim
中科院分区：
文献类型：
--
作者：
Duong, MyLinh;Islam, Shofiqul;Yusuf, Salim
1秒用力呼气容积（FEV 1）受损程度与死亡率、心血管疾病事件和呼吸系统住院率之间的关系尚不清楚，这些关系在不同人群中的变化也不清楚。我们前瞻性地招募了来自17个国家的35-70岁的成年人，这些人在4年内不打算从农村和城市社区搬家。使用便携式肺量计评估FEV 1。FEV 1值在国家内根据身高、年龄和性别进行标准化，并表示为国家特异性FEV 1预测值（FEV1%）的百分比。FEV1%分为无损害（FEV1% >= 0 SD，与国家特异性平均值相比）、轻度损害（FEV1%
Background The associations between the extent of forced expiratory volume in 1 s (FEV1) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations might vary across populations is unknown.Methods In this international, community-based cohort study, we prospectively enrolled adults aged 35-70 years who had no intention of moving residences for 4 years from rural and urban communities across 17 countries. A portable spirometer was used to assess FEV1. FEV1 values were standardised within countries for height, age, and sex, and expressed as a percentage of the country-specific predicted FEV1 value (FEV1%). FEV1% was categorised as no impairment (FEV1% >= 0 SD from country-specific mean), mild impairment (FEV1%