Regulation of the basement membrane by epithelia generated forces.
Regulation of the basement membrane by epithelia generated forces.
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DOI：
10.1088/1478-3975/9/6/065003
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发表时间：
2012-12
期刊：
影响因子：
2
通讯作者：
Tanner K
中科院分区：
文献类型：
--
作者：
Tanner K
肿瘤转移涉及组织结构的逐渐丧失和上皮和结缔组织之间结构边界的溶解。基底膜（BM）是细胞外基质蛋白的一个特殊网络，它形成了一个物理上限制侵袭前病变的屏障，使它们仍然是局部的损害。基底膜不是一个静态的结构，而是一个在成年生物体中不断再生和重塑的结构。基质组织也调节细胞功能。因此，细胞外基质蛋白的合成、重塑和蛋白水解降解平衡的改变可能导致结构完整性的丧失。然而，体内基底膜复杂结构特性的重新组装和维持仍然难以捉摸。在此，本文重点介绍了目前对基底膜的结构特性和建立的认识，并讨论了自生力在成人组织重塑和基底膜作为恶性肿瘤抑制因子的维持中的潜在作用。
Tumor metastasis involves a progressive loss of tissue architecture and dissolution of structural boundaries between the epithelium and connective tissue. The basement membrane (BM), a specialized network of extracellular matrix proteins forms a barrier that physically restricts pre- invasive lesions such that they remain as local insults. The BM is not a static structure, but one that is constantly regenerated and remodeled in the adult organism. Matrix organization also regulates cell function. Thus alterations in the balance of synthesis, remodeling and proteolytic degradation of the extracellular matrix proteins may contribute to a loss of structural integrity. However, the de novo assembly and maintenance of the complex structural properties of in vivo basement membranes remain elusive. Here, this paper highlights the current understanding on the structural properties and the establishment of the BM, and discusses the potential role of self-generated forces in adult tissue remodeling and the maintenance of the BM as a malignancy suppressor.