Potential human exposures to neonicotinoid insecticides: A review.
Potential human exposures to neonicotinoid insecticides: A review.
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DOI：
10.1016/j.envpol.2017.12.101
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发表时间：
2018-05
影响因子：
8.9
通讯作者：
Q. Zhang;Z. Li;C. H. Chang;J. Lou;M. Zhao;C. Lu
中科院分区：
文献类型：
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作者：
Q. Zhang;Z. Li;C. H. Chang;J. Lou;M. Zhao;C. Lu
由于其内吸特性和对昆虫的高效控制，烟碱类杀虫剂（neonics）自1990年初引入以来已广泛用于全球农业。最近的研究表明，neonics可能无处不在，一旦应用，在环境中具有更长的生物半衰期，因此暗示人类暴露于neonics的可能性越来越大。尽管新生儿具有持久的特性和广泛的用途，但关于人类接触途径的科学文献相对较少。在这篇综述中，我们总结了2017年之前发表的同行评议文章的结果，这些文章讨论了通过摄入和吸入的潜在人体暴露，以及人体生物监测研究的结果。此外，我们建议使用相对效力因子法，以便于评估同时暴露于具有相似化学结构和毒理学终点的新生儿混合物。我们相信，我们在这次审查中提出的科学信息将有助于未来的评估总新生儿暴露和随后的人类健康风险表征。
Due to their systemic character and high efficacy to insect controls, neonicotinoid insecticides (neonics) have been widely used in global agriculture since its introduction in early 1990. Recent studies have indicated that neonics may be ubiquitous, have longer biological half-lives in the environment once applied, and therefore implicitly suggested the increasing probability for human exposure to neonics. Despite of neonics’ persistent characters and widespread uses, scientific literature in regard of pathways in which human exposure could occur is relatively meager. In this review, we summarized results from peer-reviewed articles published prior to 2017 that address potential human exposures through ingestion and inhalation, as well as results from human biomonitoring studies. In addition, we proposed the use of relative potency factor approach in order to facilitate the assessment of concurrent exposure to a mixture of neonics with similar chemical structures and toxicological endpoints. We believe that the scientific information that we presented in this review will aid to future assessment of total neonic exposure and subsequently human health risk characterization.