DISTRIBUTION OF AMYLOID IN THE BRAIN-STEM OF PATIENTS WITH ALZHEIMER-DISEASE
DISTRIBUTION OF AMYLOID IN THE BRAIN-STEM OF PATIENTS WITH ALZHEIMER-DISEASE
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DOI：
10.1016/0304-3940(92)90795-9
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发表时间：
1992-12-14
影响因子：
2.5
通讯作者：
STRUBLE, RG
中科院分区：
文献类型：
--
作者：
BRILLIANT, M;ELBLE, RJ;STRUBLE, RG
采用银染色法在13例阿尔茨海默病（AD）患者、6例阿尔茨海默病和帕金森病（AD- pd）混合患者、5例疾病对照和2例老年对照的死后脑干切片中鉴定出A4蛋白（β蛋白、β淀粉样蛋白）沉积。在AD和AD- pd患者中发现A4的直立-尾侧梯度，因此A4在中脑最常见，在髓质最不常见。对照组的脑干只有很少或根本没有A4。中脑顶盖和被盖的A4密度最大，但红核和网状黑质大部分未见。A4的这种分布表明，A4的沉积是突触连通性的功能，而不是来自血管源的被动扩散。
A4 protein(beta-protein, beta-amyloid) deposits were identified with silver stains in postmortem brainstem sections from 13 patients with Alzheimer disease (AD), 6 patients with mixed Alzheimer disease and Parkinson disease (AD-PD), 5 disease controls, and 2 elderly controls. A rostro-caudal gradient of A4 was found in patients with AD and AD-PD, such that A4 was most prevalent in the midbrain and least prevalent in the medulla. The brainstems of the controls contained little or no A4. The midbrain tectum and tegmentum contained the greatest densities of A4, but the red nucleus and substantia nigra pars reticulata were largely spared. This distribution of A4 suggests that A4 deposition is a function of synaptic connectivity rather than passive diffusion from vascular sources.