The Treg/Th17 Imbalance in Patients with Idiopathic Dilated Cardiomyopathy
The Treg/Th17 Imbalance in Patients with Idiopathic Dilated Cardiomyopathy
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特发性扩张型心肌病患者的 Treg/Th17 失衡
DOI：
10.1111/j.1365-3083.2010.02374.x
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发表时间：
2010-04-01
影响因子：
3.7
通讯作者：
Xia, J.
中科院分区：
文献类型：
--
作者：
Li, J.;Wang, L.;Xia, J.
To assess whether Treg/Th17 balance was broken in patients with idiopathic dilated cardiomyopathy (DCM). We studied 25 patients who were diagnosed as idiopathic DCM (18 men and seven women, mean age 35.6 +/- 5.2) and 25 normal persons (18 men and seven women, mean age 33.8 +/- 4.9). Then, we detected Treg/Th17 functions on different levels including cell frequencies, related cytokine secretion and key transcription factors in patients with idiopathic DCM and controls. The results demonstrated that patients with idiopathic DCM revealed significant increase in peripheral Th17 number, Th17-related cytokines (IL-17, IL-6, IL-23) and transcription factor (ROR gamma t) levels and obvious decrease in Treg number, Treg-related cytokines (TGF-beta 1 and IL-10) and transcription factor (Foxp3) levels when compared to normal persons. Results indicated that Treg/Th17 functional imbalance existed in patients with idiopathic DCM, suggesting a potential role for Treg/Th17 imbalance in the development of idiopathic DCM.
