Androgen and estrogen metabolism in male rhesus monkeys.
Androgen and estrogen metabolism in male rhesus monkeys.
复制标题
雄性恒河猴的雄激素和雌激素代谢。
DOI：
10.1210/endo-105-4-869
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发表时间：
1979
期刊：
影响因子：
4.8
通讯作者：
C. Longcope
中科院分区：
文献类型：
--
作者：
C. Franz;C. Longcope
用~ 3 H-标记的雄激素和~（14）C-标记的雌激素，研究了雄性恒河猴雄激素和雌激素代谢的动态。在全血中测量的睾酮（T; 140 +/- 10升/天）的平均（+/-）MCR显著小于雄烯二酮（A）、雌酮（E1）和雌二醇（E2;分别为650 +/- 8、1010 +/- 160和500 +/- 20升/天）的MCR。这些发现是兼容的特定球蛋白结合的T在这个物种。A和T的平均血液生成量分别为0.42 +/- 0.11和0.55 +/- 0.04 mg/天，E1和E2的平均血液生成量分别为40 +/- 16和13 +/-mg/天。雄激素的相互转化[A转化为T（[rho]A，TBB）和T转化为A（[rho]T，ABB）的分数转化率]没有差异，但低于雌激素的相互转化（[rho]E1，E2 BB和[rho]E2，E1 BB）。平均[rho]T、E2 BB值分别为0.015 ± 0.001和0.0024 ± 0.0003，与男性的值非常相似。PMS促性腺激素给药未改变雄激素或雌激素代谢的任何测量值，hCG导致A向T的转化率降低，T给药增加了T的MCR，雌激素给药无变化。芳构化速率不受所有处理的影响。
Using constant infusions of 3H-labeled androgens and 14C-labeled estrogens, the dynamics of androgen and estrogen metabolism have been studied in male rhesus monkeys. The mean (+/-) MCR, as measured in whole blood, for testosterone (T; 140 +/- 10 liters/day) was significantly smaller than the MCRs for androstenedione (A), estrone (E1), and estradiol (E2; 650 +/- 8, 1010 +/- 160, and 500 +/- 20 liters/day, respectively). These findings are compatible with the specific globulin binding of T in this species. The mean blood productions were 0.42 +/- 0.11 and 0.55 +/- 0.04 mg/day for A and T and 40 +/- 16 and 13 +/- micrograms/day for E1 and E2, respectively. The interconversions of the androgens [fractional conversion rates of A to T ([rho]A,TBB) and T to A ([rho]T,ABB)] were not different but were lower than the interconversions of the estrogens ([rho]E1,E2BB and [rho]E2,E1BB). The mean [rho]T,E2BB values were 0.015 +/- 0.001 and 0.0024 +/- 0.0003, which are remarkably similiar to those values in men. Administrations of PMS gonadotropin did not alter any measured values of androgen or estrogen metabolism, hCG resulted in a decrease in the conversion ratio of A to T, T administration increased the MCR of T, and estrogen administration resulted in no changes. The aromatization rate remained unaffected by all treatments.