Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
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DOI：
10.1016/s0896-6273(00)81090-9
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发表时间：
1999-02-01
期刊：
影响因子：
16.2
通讯作者：
Van Vactor, D
中科院分区：
文献类型：
--
作者：
Wills, Z;Marr, L;Van Vactor, D
神经元生长锥受细胞外信号引导的能力需要信号转导系统和前沿动态的基于肌动蛋白的细胞骨架之间的密切沟通。Profilin是一种小的肌动蛋白结合蛋白，被认为是前缘膜细胞运动机制的调节剂。然而，它在发育中的神经系统中的需求尚不清楚。Profilin与Enabled蛋白家族成员相关，表明Profilin可能将Abl功能与细胞骨架联系起来。本文通过对果蝇的遗传分析，证明了Profilin（山雀）和Abl （Abl）突变在节间神经b （ISNb）轴突中表现出相同的生长锥阻滞表型。此外，双突变体的表型表明，这些成分共同控制轴突的生长。
The ability of neuronal growth cones to be guided by extracellular cues requires intimate communication between signal transduction systems and the dynamic actin-based cytoskeleton at the leading edge. Profilin, a small, actin-binding protein, has been proposed to be a regulator of the cell motility machinery at leading edge membranes. However, its requirement in the developing nervous system has been unknown. Profilin associates with members of the Enabled family of proteins, suggesting that Profilin might link Abl function to the cytoskeleton. Here, genetic analysis in Drosophila is used to demonstrate that mutations in Profilin (chickadee) and Abl (abl) display an identical growth cone arrest phenotype for axons of intersegmental nerve b (ISNb). Moreover, the phenotype of a double mutant suggests that these components function together to control axonal outgrowth.