Kidney aging: From phenotype to genetics
Kidney aging: From phenotype to genetics
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DOI：
10.1089/rej.2005.8.101
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发表时间：
2005-06-01
影响因子：
2.6
通讯作者：
Frisina, N
中科院分区：
文献类型：
--
作者：
Buemi, M;Nostro, L;Frisina, N
衰老是一个导致人体系统结构和功能变化的生理过程，有时会导致各种器官衰竭。就肾脏而言，遗传因素和环境因素都可能影响老年人的组织损伤和相关功能丧失。另一方面，对结构变化的功能适应似乎受到老年人常见的共病状况的影响，如动脉粥样硬化和高血压。目前尚不清楚生理衰老是否不可避免地伴随着肾功能的下降或其发生的速度。衰老中组织损伤的分子机制的发现可以为干预提供新的视角。一氧化氮、氧化应激、肾素血管紧张素系统、端粒长度变化和klotho基因表达的作用是进一步深入研究衰老的重要课题。更好地了解生理性肾脏衰老可以改善这一过程的临床方法，并扩大移植提供的治疗可能性。
Aging is a physiological process that causes structural and functional changes in human body systems, sometimes leading to various organ failure.As far as the kidney is concerned, both genetic factors and environmental agents may influence the tissues damage in elderly people and the related loss of function. On the other hand, functional adaptations to structural changes appear to be compromised by co-morbid conditions that are frequently found in elderly people, such as atherosclerosis and hypertension. It is not yet known whether physiological aging is inevitably accompanied by a decline in renal function or how rapidly it might happen. The discovery of molecular mechanisms responsible for tissue damage in aging could offer new perspectives on interventions. The role, of nitric oxide, oxidative stress, the reninangiotensin system, changes in length of telomeres, and klotho gene expression are important subjects for further in-depth studies about aging. A better understanding of physiological renal aging could improve the clinical approach to this process and widen the therapeutic possibilities offered by transplantation.