Biodegradable Polyanhydrides as Encapsulation Layers for Transient Electronics
Biodegradable Polyanhydrides as Encapsulation Layers for Transient Electronics
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DOI：
10.1002/adfm.202000941
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发表时间：
2020-06-09
影响因子：
19
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Choi, Yeon Sik;Koo, Jahyun;Rogers, John A.
生物可吸收电子系统代表了一种新兴的感兴趣的技术，因为它们能够在生物环境中无害地溶解、化学降解、崩解和/或以其他方式物理消失，作为临时植入物的基础，从而避免了二次手术摘除程序的需要。聚酸酐聚合物可以作为此类系统的疏水封装层，作为更广泛的瞬变电子学领域的子集，在瞬变电子学中，生物降解最终通过链断裂发生。系统的实验研究包括在不同pH值和/或温度下浸泡在磷酸盐缓冲盐水溶液中，表明溶解是通过表面侵蚀机制进行的，几乎没有膨胀。这种聚合物的机械性能非常适合用于柔软、灵活的设备，在这种设备中，可以通过基于模具的光聚合技术进行集成。对聚合物性能与单体组成和渗透率对涂层厚度的依赖关系的研究揭示了一些潜在的影响。简单的演示说明了在完全浸泡在接近生理条件的水溶液中时，底层可生物降解电子系统维持运行的能力，持续时间从几个小时到一周不等。在动物模型中进行的系统的化学、物理和活体生物学研究显示，没有毒性或其他不良生物反应的迹象。
Bioresorbable electronic systems represent an emerging class of technology of interest due to their ability to dissolve, chemically degrade, disintegrate, and/or otherwise physically disappear harmlessly in biological environments, as the basis for temporary implants that avoid the need for secondary surgical extraction procedures. Polyanhydride-based polymers can serve as hydrophobic encapsulation layers for such systems, as a subset of the broader field of transient electronics, where biodegradation eventually occurs by chain scission. Systematic experimental studies that involve immersion in phosphate-buffered saline solution at various pH values and/or temperatures demonstrate that dissolution occurs through a surface erosion mechanism, with little swelling. The mechanical properties of this polymer are well suited for use in soft, flexible devices, where integration can occur through a mold-based photopolymerization technique. Studies of the dependence of the polymer properties on monomer compositions and the rates of permeation on coating thicknesses reveal some of the underlying effects. Simple demonstrations illustrate the ability to sustain operation of underlying biodegradable electronic systems for durations between a few hours to a week during complete immersion in aqueous solutions that approximate physiological conditions. Systematic chemical, physical, and in vivo biological studies in animal models reveal no signs of toxicity or other adverse biological responses.