Unintended Immunological Consequences of Biologic Therapy.
Unintended Immunological Consequences of Biologic Therapy.
复制标题
生物治疗的意外免疫学后果。
DOI：
10.1007/s11882-016-0624-7
复制
发表时间：
2016
影响因子：
5.5
通讯作者：
Kwan,Mildred
中科院分区：
文献类型：
--
作者：
Henrickson,SarahE;Ruffner,MelanieA;Kwan,Mildred
在自身免疫性疾病中免疫失调的理解方面的最新进展使得能够开发称为生物制剂的新的基于单克隆抗体的药物。生物制剂已被用于靶向许多疾病的异常免疫反应，但风湿病和其他自身免疫性疾病的患者受益最多，结局的改善也很显著。然而，生物制剂的使用并非没有危险，因为这些制剂会阻断用于保护宿主的免疫途径。这已经被感染率的增加以及诱导新的自身免疫和血液学不良反应所证实。随着用于治疗自身免疫性疾病的新药进入管道，执业免疫学家有责任了解这些生物制剂的机制和临床使用的意义。
Recent advances in the understanding of immune dysregulation in autoimmune diseases have enabled the development of new monoclonal antibody-based drugs called biologics. Biologics have been used to target aberrant immune responses in many diseases, but patients with rheumatologic and other autoimmune diseases have benefited the most and improvements in outcomes have been significant. The use of biologics is not without hazard, however, as these agents block immune pathways adapted to protect the host. This has been borne out by increased rates of infections as well as induction of new autoimmune and hematologic adverse effects. As new drugs for the treatment of autoimmune conditions are entering the pipeline, it is incumbent on the practicing immunologist to understand the mechanism of these biologics and the implications of clinical use.